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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: PR interval prolongation, QT interval prolongation, TORSADES DE POINTES.

Derm: rash, STEVENS-JOHNSON SYNDROME.

Endo: hypoglycemia.

GI: abdominal cramps/pain, diarrhea, nausea, vomiting, hepatotoxicity.

GU: ↓fertility (males).

Hemat: bleeding, blood dyscrasias, hemolytic anemia, HEMOLYTIC UREMIC SYNDROME, THROMBOCYTOPENIA, THROMBOTIC THROMBOCYTOPENIC PUPURA.

Misc: cinchonism, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND FEVER).

Interactions ⬆ ⬇

Drug-Drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Renal Impairment

US Brand Names ⬆ ⬇

Qualaquin

Action ⬆ ⬇

Therapeutic Effects:

Classifications ⬆ ⬇

Therapeutic Classification: antimalarials

Pharmacokinetics ⬆ ⬇

Absorption: Rapidly and almost completely (80%) absorbed following oral administration.

Distribution: Varies with condition and patient; does not enter CSF well. Crosses the placenta and enters breast milk.

Protein Binding: >90% in patients with cerebral malaria, pregnant women, and children; 85–90% in patients with uncomplicated malaria; 70% in healthy adults.

Metabolism/Excretion: >80% metabolized by the liver; metabolites have less activity than quinine; metabolites excreted in urine. 20% excreted unchanged in urine. Excretion ↑ in acidic urine.

Half-life: 11 hr (↑ in patients with malaria).

Time/Action Profile ⬆ ⬇

(antimalarial blood levels)

ROUTEONSETPEAKDURATION
POunknown3.2–5.9 hr8 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

KWI-nine

Code ⬆

NDC Code*