Contraindicated in:
Use Cautiously in:
CV: QT interval prolongation, AORTIC ANEURYSM/DISSECTION, TORSADE DE POINTES.
Derm: photosensitivity, STEVENS-JOHNSON SYNDROME.
Endo: hyperglycemia, hypoglycemia.
GI: diarrhea, nausea, ↑ liver enzymes, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), abdominal pain, dyspepsia, vomiting.
MS: arthralgia, myalgia, tendinitis, tendon rupture.
Neuro: agitation, anxiety, confusion, depression, dizziness, ELEVATED INTRACRANIAL PRESSURE (INCLUDING PSEUDOTUMOR CEREBRI), hallucinations, headache, insomnia, nightmares, paranoia, peripheral neuropathy, SEIZURES, SUICIDAL THOUGHTS, toxic psychosis, tremor.
Drug-Drug:
Spectrum:
Absorption: Well absorbed (90%) following oral administration.
Distribution: Widely distributed; tissue concentrations may exceed plasma concentrations.
Metabolism/Excretion: Mostly metabolized by the liver; 20% excreted unchanged in urine, 25% excreted unchanged in feces.
Half-life: 12 hr.
NDC Code*