cosyntropin

Contraindicated in:

Hypersensitivity.

Use Cautiously in:

OB: Pregnancy or lactation (safety not established).

Adv. Reactions/Side Effects ⬆ ⬇

Misc: ANAPHYLAXIS HYPERSENSITIVITY REACTIONS INCLUDING

Interactions ⬆ ⬇

Drug-drug:

Corticosteroids, estrogens, and spironolactone alter the results of testing.

Availability ⬆ ⬇

(Generic available)

Powder for injection: 0.25 mg/vial

Route/Dosage ⬆ ⬇

IM IV (Adults and Children >2 yr): 0.25 mg.
IM IV (Children <2 yr): 0.125 mg.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

A synthetic form of corticotropin (ACTH); stimulates the adrenal gland to primarily produce corticosteroids (hydrocortisone) and a small amount of mineralocorticoids (aldosterone). Action requires intact adrenal responsiveness.

Therapeutic effects:

Production of adrenal steroids after administration.

Classifications ⬆ ⬇

Therapeutic Classification: diagnostic agents, hormones (adrenocorticotropic)

Pharmacologic Classification: hormones

Pharmacokinetics ⬆ ⬇

Absorption: Rapidly absorbed.

Distribution: Removed from plasma to many tissues.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(effects on plasma cortisol levels)

ROUTE	ONSET	PEAK	DURATION
IM, IV	5 min	45–60 min	unknown

Patient/Family Teaching ⬆ ⬇

Explain purpose of cosyntropin and need for lab tests.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

0548- Amphastar Pharmaceuticals, Inc.
- 0548-5900- Cortrosyn
  - 0548-5900-00- 10 VIAL in 1 CARTON (0548-5900-00) > 1 mL in 1 VIAL

0781- Sandoz Inc
- 0781-3440- Cosyntropin
  - 0781-3440-95- 10 VIAL in 1 CARTON (0781-3440-95) > 1 mL in 1 VIAL (0781-3440-71)

50090- A-S Medication Solutions
- 50090-4547- Cortrosyn
  - 50090-4547-1- 1 mL in 1 VIAL (50090-4547-1)

67457- Mylan Institutional LLC
- 67457-227- Cosyntropin
  - 67457-227-02- 10 VIAL in 1 CARTON (67457-227-02) > 1 mL in 1 VIAL (67457-227-00)

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Indications ⬇

Contraind./Precautions ⬆ ⬇