• HIV-1 infection.

Contraindicated in:

• Hypersensitivity to any component (especially abacavir, rechallenge may be fatal)
• Resistance to any component
• Presence of HLA-B*5701 allele
• Concurrent use of dofetilide
• Concurrent administration of lamivudine or abacavir alone or in other combination antiretroviral dose forms
• Hepatic impairment
• CCr <30 mL/min
• OB: Avoid use through first trimester of pregnancy (may ↑ risk of neural tube defects)
• Lactation: Breastfeeding not recommended for patients with HIV.

Use Cautiously in:

• Underlying hepatitis B or C (may worsen liver function)
• Women and obesity (↑ risk of lactic acidosis and severe hepatomegaly with steatosis)
• Underlying cardiovascular disease, including history of hypertension, hyperlipidemia, smoking history, or diabetes mellitus
• OB: Can consider use during second or third trimester if potential maternal benefit justifies potential fetal risk
• Pedi: Children <6 kg (safety and effectiveness not established).

CV: MI.

F and E: LACTIC ACIDOSIS.

GI: exacerbation of hepatitis B, HEPATOMEGALY (WITH STEATOSIS), HEPATOTOXICITY (↑ WITH HEPATITIS B OR C).

Neuro: fatigue, headache, insomnia.

Misc: HYPERSENSITIVITY REACTIONS, immune reconstitution syndrome.

Drug-Drug:

• Abacavir: Alcohol↑ blood levels.
• May ↑ methadone metabolism in some patients; slight ↑ in methadone dosing may be needed.
• May ↑ levels and toxicity of riociguat; may need to ↓ riociguat dose.
• Combination therapy with tenofovir and abacavir may lead to virologic nonresponse; avoid use.
• Dolutegravir: May ↑ levels and toxicity from dofetilide; concurrent use contraindicated.
• Levels and effectiveness are ↓ by etravirine (should not be used concurrently without atazanavir/ritonavir, darunavir/ritonavir or lopinavir/ritonavir).
• Levels and effectiveness are ↓ by efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, and rifampin; ↑ dosage of dolutegravir recommended.
• Levels and effectiveness may be ↓ by nevirapine; avoid concurrent use
• May ↑ levels and toxicity from metformin.
• Levels and effectiveness may be ↓ by other metabolic inducers including oxcarbazepine, phenobarbital, and phenytoin; avoid concurrent use.
• Absorption and effectiveness may be ↓ by cation-containing antacids or laxatives, as well as buffered medications, or sucralfate; should be taken 2 hr before or 6 hr after these medications.
• Absorption and effectiveness may be ↓ by calcium supplements (oral) or iron supplements (oral); under fasting conditions, abacavir/dolutegravir/lamivudine should be taken 2 hr before or 6 hr after these medications; when taken with food, abacavir/dolutegravir/lamivudine and calcium or iron supplements may be taken at the same time.
• May ↑ dalfampridine levels and risk of seizures.
• Lamivudine: Trimethoprim/sulfamethoxazole↑ levels (dose alteration may be necessary in renal impairment).
• ↑risk of pancreatitis with concurrent use of other drugs causing pancreatitis.
• ↑risk of neuropathy with concurrent use of other drugs causing neuropathy.
• Sorbitol may ↓ levels; avoid concurrent use.

Drug-Natural Products:

• Levels and effectiveness may be ↓ St. John's wort; avoid concurrent use.

(Generic available)

• Tablets: abacavir 600 mg/dolutegravir 50 mg/lamivudine 300 mg;
• Tablets for oral suspension: abacavir 60 mg/dolutegravir 5 mg/lamivudine 30 mg;

Tablets and tablets for oral suspension are NOT interchangeable on a milligram-per-milligram basis.

• PO (Adults and Children 25 kg): Triumeq: One tablet (abacavir 600 mg/dolutegravir 50 mg/lamivudine 300 mg) once daily; Concurrent efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, or rifampin: additional 50–mg dose of dolutegravir (Tivicay) is required separated from Triumeq by 12 hr.
• PO (Children 20–<25 kg): Triumeq PD: Six tablets once daily (total dose = abacavir 360 mg/dolutegravir 30 mg/lamivudine 180 mg). Concurrent efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, or rifampin: additional 30–mg dose of dolutegravir (Tivicay PD) is required separated from Triumeq PD by 12 hr.
• PO (Children 14–<20 kg): Triumeq PD: Five tablets once daily (total dose = abacavir 300 mg/dolutegravir 25 mg/lamivudine 150 mg). Concurrent efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, or rifampin: additional 25–mg dose of dolutegravir (Tivicay PD) is required separated from Triumeq PD by 12 hr.
• PO (Children 10–<14 kg): Triumeq PD: Four tablets once daily (total dose = abacavir 240 mg/dolutegravir 20 mg/lamivudine 120 mg). Concurrent efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, or rifampin: additional 20–mg dose of dolutegravir (Tivicay PD) is required separated from Triumeq PD by 12 hr.
• PO (Children 6–<10 kg): Triumeq PD: Three tablets once daily (total dose = abacavir 180 mg/dolutegravir 15 mg/lamivudine 90 mg). Concurrent efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, or rifampin: additional 15-mg dose of dolutegravir (Tivicay PD) is required separated from Triumeq PD by 12 hr.

Triumeq, Triumeq PD

• Abacavir: Converted inside cells to carbovir triphosphate, its active metabolite. Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase, which in turn terminates viral DNA growth.
• Dolutegravir: Inhibits HIV-1 integrase, which is required for viral replication.
• Lamivudine: After intracellular conversion to its active form (lamivudine-5-triphosphate), inhibits viral DNA synthesis by inhibiting the enzyme reverse transcriptase.

• Evidence of decreased viral replication and reduced viral load with slowed progression of HIV and its sequelae.

Therapeutic Classification: antiretrovirals (combination)

Pharmacologic Classification: integrase strand transfer inhibitors (INSTI) (dolutegravir), nucleoside reverse transcriptase inhibitors (abacavir, lamivudine)

Abacavir

Absorption: Rapidly and extensively (83%) absorbed.

Distribution: Distributes into extravascular space and readily distributes into erythrocytes.

Metabolism/Excretion: Mostly metabolized by the liver; 1.2% excreted unchanged in urine.

Half-life: 1.5 hr.

Dolutegravir

Absorption: Absorption follows oral administration; bioavailability is unknown.

Distribution: Enters CSF.

Protein Binding: >98.9%.

Metabolism/Excretion: Metabolized primarily by the UGT1A1 enzyme system with some metabolism by CYP3A4. 53% excreted unchanged in feces. Metabolites are renally excreted, minimal renal elimination of unchanged drug. Poor metabolizers of dolutegravir have ↑ levels and ↓ clearance.

Half-life: 14 hr.

Lamivudine

Absorption: Well absorbed after oral administration (86% in adults, 66% in infants and children).

Distribution: Distributes into the extravascular space. Some penetration into CSF; remainder of distribution unknown.

Metabolism/Excretion: Mostly excreted unchanged in urine; <5% metabolized by the liver.

Half-life: 13–19 hr.

(plasma concentrations)

• Emphasize the importance of taking Triumeq as directed. Must always be used in combination with other antiretroviral drugs. Do not take more than prescribed amount, and do not stop taking without consulting health care professional. Take missed doses as soon as remembered unless almost time for next dose; do not double doses. Advise patient to read the Medication Guide prior to starting therapy and with each Rx refill in case of changes.
• Instruct patient or caregiver in how to disperse Triumeq PD tablets.
• Instruct patient not to share medication with others.
• Inform patient that medication does not cure HIV or prevent associated or opportunistic infections. Medication may reduce the risk of transmission of HIV to others through sexual contact or blood contamination. Caution patient to use a condom, and avoid sharing needles or donating blood to prevent spreading HIV to others. Advise patient that the long-term effects of medication are unknown at this time.
• Advise patient of potential for hypersensitivity reactions that may result in death. Instruct patient to discontinue medication and notify health care professional immediately if symptoms of hypersensitivity or signs of Immune Reconstitution Syndrome (signs and symptoms of inflammation from previous infections) occur. A warning card summarizing symptoms of hypersensitivity is provided with each prescription; instruct patient to carry card at all times.
• Instruct patient to notify health care professional immediately if symptoms of lactic acidosis (tiredness or weakness, unusual muscle pain, trouble breathing, stomach pain with nausea and vomiting, cold especially in arms or legs, dizziness, fast or irregular heartbeat) or if signs of hepatotoxicity (yellow skin or whites of eyes, dark urine, light-colored stools, lack of appetite for several days or longer, nausea, abdominal pain) occur. These symptoms may occur more frequently in patients that are female, obese, or have been taking medications for a long time.
• Instruct patient to notify health care professional promptly if signs of peripheral neuropathy or pancreatitis occur.
• Advise patient to avoid sugarless gum or candy due to sorbitol content; may ↓ medication effectiveness.
• Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications, especially methadone, St. John's wort, and other antiretrovirals.
• Rep: May cause fetal harm and increase risk of neural tube defects. Advise adolescent and adult females of reproductive potential to use effective contraception and to avoid breastfeeding during therapy. Notify care professional if pregnancy is planned or suspected. Switch to another antiviral regimen during 1st trimester; may increase risk of neural tube defects. May consider Triumeq during 2nd and 3rd trimesters of pregnancy if expected benefit justifies potential risk to pregnant woman and fetus. Pregnant patients should be encouraged to enroll in the Antiretroviral Pregnancy Registry by calling 1-800-258-4263.
• Advise patient to carry hypersensitivity warning card with them at all times.
• Emphasize the importance of regular follow-up exams and blood counts to determine progress and monitor for side effects.

ah-BACK-ah-veer/doe-loo-TEG-ra-vir/la-MI-vyoo-deen

NDC Code^*

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-5382- Abacavir and Lamivudine
    • 0093-5382-56- 1 BOTTLE in 1 CARTON (0093-5382-56) > 30 TABLET, FILM COATED in 1 BOTTLE

• 35573- Burel Pharma
  • 35573-402- Abacavir and Lamivudine
    • 35573-402-30- 1 BOTTLE in 1 CARTON (35573-402-30) > 30 TABLET, FILM COATED in 1 BOTTLE

• 35573- Burel Pharma
  • 35573-430- Abacavir and Lamivudine
    • 35573-430-30- 1 BOTTLE in 1 CARTON (35573-430-30) > 30 TABLET, FILM COATED in 1 BOTTLE

• 42291- AvKARE, Inc.
  • 42291-115- Abacavir and Lamivudine
    • 42291-115-30- 1 BOTTLE in 1 CARTON (42291-115-30) > 30 TABLET, FILM COATED in 1 BOTTLE

• 49702- ViiV Healthcare Company
  • 49702-206- EPZICOM
    • 49702-206-13- 30 TABLET, FILM COATED in 1 BOTTLE (49702-206-13)

• 50090- A-S Medication Solutions
  • 50090-0874- EPZICOM
    • 50090-0874-0- 30 TABLET, FILM COATED in 1 BOTTLE (50090-0874-0)

• 65862- Aurobindo Pharma Limited
  • 65862-335- Abacavir and Lamivudine
    • 65862-335-10- 10 BLISTER PACK in 1 CARTON (65862-335-10) > 10 TABLET, FILM COATED in 1 BLISTER PACK

• 65862- Aurobindo Pharma Limited
  • 65862-335- Abacavir and Lamivudine
    • 65862-335-30- 1 BOTTLE in 1 CARTON (65862-335-30) > 30 TABLET, FILM COATED in 1 BOTTLE

• 65862- Aurobindo Pharma Limited
  • 65862-900- Abacavir and Lamivudine
    • 65862-900-30- 1 BOTTLE in 1 CARTON (65862-900-30) > 30 TABLET, FILM COATED in 1 BOTTLE

• 66993- Prasco Laboratories
  • 66993-482- Abacavir and Lamivudine
    • 66993-482-30- 30 TABLET, FILM COATED in 1 BOTTLE (66993-482-30)

• 68180- Lupin Pharmaceuticals, Inc.
  • 68180-288- Abacavir and Lamivudine
    • 68180-288-06- 30 TABLET, FILM COATED in 1 BOTTLE (68180-288-06)

• 68180- Lupin Pharmaceuticals, Inc.
  • 68180-288- Abacavir and Lamivudine
    • 68180-288-09- 90 TABLET, FILM COATED in 1 BOTTLE (68180-288-09)

• 68180- Lupin Pharmaceuticals, Inc.
  • 68180-288- Abacavir and Lamivudine
    • 68180-288-33- 750 TABLET, FILM COATED in 1 POUCH (68180-288-33)

• 69097- Cipla USA Inc.
  • 69097-362- Abacavir and Lamivudine
    • 69097-362-02- 30 TABLET, FILM COATED in 1 BOTTLE (69097-362-02)

• 70518- REMEDYREPACK INC.
  • 70518-0691- EPZICOM
    • 70518-0691-0- 30 TABLET, FILM COATED in 1 BLISTER PACK (70518-0691-0)

• 70518- REMEDYREPACK INC.
  • 70518-0715- Abacavir and Lamivudine
    • 70518-0715-0- 30 TABLET, FILM COATED in 1 BLISTER PACK (70518-0715-0)

• 70710- Zydus Pharmaceuticals (USA) Inc.
  • 70710-1049- Abacavir and lamivudine
    • 70710-1049-3- 30 TABLET, FILM COATED in 1 BOTTLE (70710-1049-3)

• 70710- Zydus Pharmaceuticals (USA) Inc.
  • 70710-1049- Abacavir and lamivudine
    • 70710-1049-9- 90 TABLET, FILM COATED in 1 BOTTLE (70710-1049-9)

• 70771- Cadila Healthcare Limited
  • 70771-1053- Abacavir and lamivudine
    • 70771-1053-3- 30 TABLET, FILM COATED in 1 BOTTLE (70771-1053-3)

• 70771- Cadila Healthcare Limited
  • 70771-1053- Abacavir and lamivudine
    • 70771-1053-9- 90 TABLET, FILM COATED in 1 BOTTLE (70771-1053-9)