Suppression/Prophylaxis of Malaria
- PO (Adults): 300 mg once weekly, starting 2 wk prior to entering endemic areas and for 8 wk afterward. If suppressive therapy is not initiated prior to entering endemic area, initial dose should be 300 mg followed by another 300 mg dose 6 hr later, followed by the usual dose regimen.
- PO (Children): 5 mg/kg once weekly, starting 2 wk prior to entering endemic areas and for 8 wk afterward (not to exceed 300 mg/day). If suppressive therapy is not initiated prior to entering endemic area, initial dose should be 5 mg/kg followed by another 5 mg/kg dose 6 hr later, followed by the usual dose regimen.
Treatment of Acute Attack of Malaria
- PO (Adults): 600 mg initially, then 300 mg at 6–8 hr, 24 hr, and 48 hr after initial dose.
- PO (Children): 10 mg/kg initially (not to exceed 600 mg), then 5 mg/kg at 6 hr, 24 hr, and 48 hr after initial dose (not to exceed 300 mg/day).
Extraintestinal Amebiasis
- PO (Adults): 600 mg once daily for 2 days, then 300 mg once daily for at least 2–3 wk (in combination with other antiprotozoals).
- PO (Children): 10 mg/kg (not to exceed 300 mg/day for 2–3 wk.
Rheumatoid Arthritis/Systemic Lupus Erythematosus
- PO (Adults): 150 mg once daily; ↓ dosage following maximal response.