Contraindicated in:
Use Cautiously in:
CV: edema, HF.
EENT: macular edema.
GI: ↑liver enzymes, LIVER FAILURE.
GU: BLADDER CANCER.
Hemat: anemia.
MS: fractures (arm, hand, foot) (females), RHABDOMYOLYSIS.
Drug-Drug:
Drug-Natural Products:
(Generic available)
Absorption: Well absorbed following oral administration.
Distribution: Well distributed to tissues.
Protein Binding: >99%. Active metabolites are also highly (>99%) bound.
Metabolism/Excretion: Extensively metabolized by the liver via the CYP2C8 isoenzyme); at least two metabolites have pharmacologic activity. Primarily excreted in feces and urine as metabolites.
Half-life: Pioglitazone: 3–7 hr; total pioglitazone (pioglitazone plus metabolites): 16–24 hr.
NDC Code*