Contraindicated in:
Use Cautiously in:
CV: peripheral edema, HF, CAPILLARY LEAK SYNDROME.
GI: ↓appetite, constipation, diarrhea, hepatotoxicity, nausea, vomiting.
GU: ↑serum creatinine, ↓ fertility, renal failure.
Hemat: anemia, neutropenia, thrombocytopenia.
Local: extravasation.
MS: ↑creatine kinase, arthralgia, myalgia, RHABDOMYOLYSIS.
Neuro: fatigue, headache, insomnia.
Resp: dyspnea.
Drug-Drug:
Drug-Natural Products:
Hepatic Impairment
Absorption: IV administration results in complete bioavailability.
Distribution: Extensively distributed.
Protein Binding: 97%.
Metabolism/Excretion: Primarily metabolized via CYP3A in liver to inactive metabolites. 58% excreted in feces and 6% in urine (primarily as metabolites).
Half-life: 175 hr.
NDC Code*