zoster vaccine, live

Contraindicated in:

History of anaphylactic/anaphylactoid reactions to gelatin, neomycin, or other vaccine components;
Primary/acquired immunodeficiency states (including leukemia, lymphoma, AIDS);
Concurrent immunosupressive medications (including high dose corticosteroids);
Acute febrile illness (>38.5° C or 101.3° F;
Active untreated tuberculosis;
OB: Pregnancy;
Pedi: Children.

Use Cautiously in:

OB: Child-bearing potential (pregnancy should be avoided for 3 mo following vaccination);
OB: Lactation.

Adv. Reactions/Side Effects ⬆ ⬇

Local: swelling, redness, pain, swelling

Interactions ⬆ ⬇

Drug-drug:

Concurrent immunosupressants including antineoplastics and high dose corticosteroids may ↓ response to and ↑ risk of adverse reactions.
Pneumococcal vaccine (Pneumovax 23) may ↓ response; do not administer concomitantly.

Availability ⬆ ⬇

Lyophylized powder for injection (with diluent): at least 19,400 PFU/0.65 mL

Route/Dosage ⬆ ⬇

SC (Adults ≥50 yr): 0.65 mL (contents of 1 vial).

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Boosts immunity by actively immunizing against the varicella-zoster virus.

Therapeutic effects:

Reduced risk of shingles and its sequelae.

Classifications ⬆ ⬇

Therapeutic Classification: vaccines/immunizing agents

Pharmacologic Classification: active immunizer

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following subcut administration.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

ROUTE	ONSET	PEAK	DURATION
SC	unknown	unknown	unknown

Patient/Family Teaching ⬆ ⬇

Explain purpose of vaccine to patient. Provide patient with a copy of the Patient Information Sheet.
Advise patient to notify health care professional if pregnancy is planned or expected. Pregnancy should be avoided for 3 mo after administration of vaccine.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

0006- Merck Sharp and Dohme Corp.
- 0006-4963- ZOSTAVAX
  - 0006-4963-00- 1 VIAL, SINGLE-DOSE in 1 CARTON (0006-4963-00) > .65 mL in 1 VIAL, SINGLE-DOSE (0006-4963-01)

0006- Merck Sharp and Dohme Corp.
- 0006-4963- ZOSTAVAX
  - 0006-4963-41- 10 VIAL, SINGLE-DOSE in 1 CARTON (0006-4963-41) > .65 mL in 1 VIAL, SINGLE-DOSE (0006-4963-01)

section name header

Indications ⬇

Contraind./Precautions ⬆ ⬇