Herpes Zoster
- PO (Adults): 1 g 3 times daily for 7 days.
Renal Impairment
- PO (Adults): CCr 30–49 mL/min: 1 g every 12 hr. CCr 10–29 mL/min: 1 g every 24 hr. CCr <10 mL/min: 500 mg every 24 hr.
Genital Herpes
- PO (Adults): Initial treatment: 1 g twice daily for 10 days. Recurrence: 500 mg twice daily for 3 days. Suppression of recurrence: 1 g once daily or 500 mg once daily in patients experiencing <10 recurrences/yr. Suppression of recurrence in HIV-infected patients: 500 mg every 12 hr. Reduction of transmission: 500 mg once daily for source partner.
Renal Impairment
- PO (Adults): CCr 10–29 mL/min: 1 g every 24 hr for initial treatment of genital herpes, 500 mg every 24 hr for treatment of recurrent episodes of genital herpes, 500 mg every 48 hr for suppression of genital herpes in patients with 9 or fewer recurrences/yr, 500 mg every 24 hr for suppression of genital herpes in patients with
10 recurrences/yr or HIV-infected patients. CCr <10 mL/min: 500 mg every 24 hr for initial treatment of genital herpes, 500 mg every 24 hr for treatment of recurrent episodes of genital herpes, 500 mg every 48 hr for suppression of genital herpes in patients with 9 or fewer recurrences/yr, 500 mg every 24 hr for suppression of genital herpes in patients with 10 recurrences/yr or HIV-infected patients.
Herpes Labialis
- PO (Adults and Children 12 yr): 2 g initially, then 2 g 12 hr later.
Renal Impairment
- PO (Adults): CCr 30–49 mL/min: 1 g initially, then 1 g 12 hr later. CCr 10–29 mL/min: 500 mg initially, then 500 mg 12 hr later. CCr <10 mL/min: 500 mg as a single dose.
Chickenpox
- PO (Children 2 yr): 20 mg/kg 3 times daily for 5 days (not to exceed 1 g 3 times daily).