- IV (Adults ): Antiarrhythmic: 500-mcg/kg loading dose over 1 min initially, followed by 50-mcg/kg/min infusion for 4 min; if no response within 5 min, give 2nd loading dose of 500 mcg/kg over 1 min; then ↑ infusion to 100 mcg/kg/min for 4 min. If no response, repeat loading dose of 500 mcg/kg over 1 min and ↑ infusion rate by 50-mcg/kg/min increments (not to exceed 200 mcg/kg/min for 48 hr). As therapeutic end point is achieved, eliminate loading doses and decrease dose increments to 25 mg/kg/min. Intraoperative antihypertensive/antiarrhythmic: 250–500-mcg/kg loading dose over 1 min initially, followed by 50-mcg/kg/min infusion for 4 min; if no response within 5 min, give 2nd loading dose of 250–500 mcg/kg over 1 min;, then ↑ infusion to 100 mcg/kg/min for 4 min. If no response, repeat loading dose of 250–500 mcg/kg over 1 min and ↑ infusion rate by 50-mcg/kg/min increments (not to exceed 200 mcg/kg/min for 48 hr).
- IV (Children ): Antiarrhythmic: 50 mcg/kg/min, may be ↑ every 10 min up to 300 mcg/kg/min.
