Cutaneous fungal infections including cutaneous candidiasis (lotion and cream only), tinea pedis (athlete’s foot) (gel, lotion, and cream only), tinea cruris (jock itch) (lotion and cream only), tinea corporis (ringworm) (gel, lotion, and cream only), tinea versicolor (lotion and cream only), seborrheic dermatitis (shampoo and gel only), and onychomycosis of fingernails and toenails (nail lacquer only).
Contraind./Precautions⬆⬇
Contraindicated in:
Hypersensitivity to active ingredients, additives, preservatives, or bases;
Some products contain alcohol (nail lacquer) and should be avoided in patients with known intolerance;
.
Use Cautiously in:
OB: Safety not established in pregnancy;
Lactation: Safety not established in breastfeeding;
Pedi: Safety and effectiveness not established in children <16 yr (gel and shampoo), <12 yr (topical solution), or <10 yr (cream and lotion).
Adv. Reactions/Side Effects⬆⬇
Local: burning, itching, local hypersensitivity reactions, redness, stinging
Interactions⬆⬇
Drug-drug:
Not known.
Availability⬆⬇
(Generic available)
Cream: 0.77%; 1%
Gel: 0.77%
Lotion: 1%
Nail lacquer: 8%
Shampoo: 1%; 1.5%
Suspension: 0.77%
Route/Dosage⬆⬇
(Adults and Children ≥16 yr): Shampoo:Apply 5 mL (10 mL may be used for long hair) to scalp and leave on for 3 min before rinsing off. Use twice weekly (wait at least 3 days between treatments) for 4 wk. Gel: Apply twice daily for 4 wk.
(Adults and Children ≥12 yr): Topical solution (nail lacquer): Apply to nails once daily (at bedtime or 8 hr before bathing) for up to 48 wk. Each daily application should be made over the previous coat and then removed with alcohol every 7 days.
(Adults and Children ≥10 yr): Cream/lotion: Apply twice daily for 2–4 wk.
Inhibits the transport of essential elements in fungal cell, disrupting the synthesis of DNA, RNA, and protein.
Therapeutic effects:
Decrease in symptoms of fungal infection.
Classifications⬆⬇
Therapeutic Classification: antifungals (topical)
Pharmacokinetics⬆⬇
Absorption: Absorption through intact skin is minimal (<5%).
Distribution: Distribution after topical administration is primarily local.
Metabolism/Excretion: Eliminated by kidneys (3–10% for gel).
Half-Life: 5.5 hr (gel).
Canadian Brand Names⬆⬇
Stieprox
Time/Action Profile⬆⬇
ROUTE
ONSET
PEAK
DURATION
Top
unknown
unknown
unknown
Patient/Family Teaching⬆⬇
Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes.
Caution patient that some products may stain fabric, skin, or hair. Check label information. Fabrics stained from cream or lotion can usually be cleaned by handwashing with soap and warm water.
Patients with athlete’s foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
Advise patient to report increased skin irritation or lack of response to therapy to health care professional.
Nail lacquer: File away loose nail and trim nails every 7 days after solution is removed with alcohol. Do not use nail polish on treated nails. Inform health care professional if have diabetes mellitus before using.
Inform patient that early relief of symptoms may be seen in 2–3 days but that full therapeutic response may take 3–4 wk. Recurrent fungal infections may be a sign of systemic illness.
Pronunciation⬆⬇
sye-kloe-PEER-ox
Code⬆
NDC Code
0168- E. Fougera and Co. a division of Fougera Pharmaceuticals Inc.
0168-0449- Ciclopirox
0168-0449-04- 1 BOTTLE in 1 CARTON (0168-0449-04) > 120 mL in 1 BOTTLE
0168- E. Fougera and Co. a division of Fougera Pharmaceuticals Inc.
0168-0522- Ciclopirox
0168-0522-04- 1 BOTTLE, PLASTIC in 1 CARTON (0168-0522-04) > 120 mL in 1 BOTTLE, PLASTIC
0187- Bausch Health Americas, Inc.
0187-5180- Penlac
0187-5180-06- 6.6 mL in 1 BOTTLE, WITH APPLICATOR (0187-5180-06)
0574- Paddock Laboratories, LLC
0574-2061- CICLOPIROX
0574-2061-01- 1 TUBE in 1 CARTON (0574-2061-01) > 100 g in 1 TUBE
0574- Paddock Laboratories, LLC
0574-2061- CICLOPIROX
0574-2061-30- 1 TUBE in 1 CARTON (0574-2061-30) > 30 g in 1 TUBE
0574- Paddock Laboratories, LLC
0574-2061- CICLOPIROX
0574-2061-45- 1 TUBE in 1 CARTON (0574-2061-45) > 45 g in 1 TUBE
0591- Actavis Pharma, Inc.
0591-2159- Ciclopirox
0591-2159-90- 120 mL in 1 BOTTLE, PLASTIC (0591-2159-90)
0713- Gand W Laboratories, Inc.
0713-0317- Ciclopirox
0713-0317-87- 1 BOTTLE, WITH APPLICATOR in 1 CARTON (0713-0317-87) > 3.3 mL in 1 BOTTLE, WITH APPLICATOR
0713- Gand W Laboratories, Inc.
0713-0317- Ciclopirox
0713-0317-88- 1 BOTTLE, WITH APPLICATOR in 1 CARTON (0713-0317-88) > 6.6 mL in 1 BOTTLE, WITH APPLICATOR
0713- Gand W Laboratories, Inc.
0713-0638- Ciclopirox Olamine
0713-0638-15- 1 TUBE in 1 BOX (0713-0638-15) > 15 g in 1 TUBE
0713- Gand W Laboratories, Inc.
0713-0638- Ciclopirox Olamine
0713-0638-18- 1 TUBE in 1 BOX (0713-0638-18) > 90 g in 1 TUBE
0713- Gand W Laboratories, Inc.
0713-0638- Ciclopirox Olamine
0713-0638-31- 1 TUBE in 1 BOX (0713-0638-31) > 30 g in 1 TUBE
42192- Acella Pharmaceuticals, LLC
42192-714- Ciclopirox
42192-714-01- 1 KIT in 1 CARTON (42192-714-01) * 6.6 mL in 1 BOTTLE, WITH APPLICATOR * 28 mL in 1 BOTTLE
42192- Acella Pharmaceuticals, LLC
42192-715- Ciclopirox
42192-715-06- 1 BOTTLE in 1 CARTON (42192-715-06) > 6.6 mL in 1 BOTTLE
43538- Medimetriks Pharmaceuticals, Inc.
43538-500- Ciclodan
43538-500-06- 6.6 mL in 1 BOTTLE, WITH APPLICATOR (43538-500-06)
43538- Medimetriks Pharmaceuticals, Inc.
43538-540- Loprox
43538-540-90- 1 TUBE in 1 CARTON (43538-540-90) > 90 g in 1 TUBE
43538- Medimetriks Pharmaceuticals, Inc.
43538-541- Loprox
43538-541-90- 1 KIT in 1 CARTON (43538-541-90) * 454 g in 1 BOTTLE, PUMP * 90 g in 1 TUBE
43538- Medimetriks Pharmaceuticals, Inc.
43538-550- Loprox
43538-550-60- 1 BOTTLE in 1 CARTON (43538-550-60) > 60 mL in 1 BOTTLE
43538- Medimetriks Pharmaceuticals, Inc.
43538-551- Loprox
43538-551-60- 1 KIT in 1 CARTON (43538-551-60) * 60 mL in 1 BOTTLE * 454 g in 1 BOTTLE, PUMP
45802- Perrigo New York Inc
45802-138- Ciclopirox Olamine
45802-138-11- 1 TUBE in 1 CARTON (45802-138-11) > 30 g in 1 TUBE
45802- Perrigo New York Inc
45802-138- Ciclopirox Olamine
45802-138-18- 1 TUBE in 1 CARTON (45802-138-18) > 90 g in 1 TUBE
45802- Perrigo New York Inc
45802-138- Ciclopirox Olamine
45802-138-35- 1 TUBE in 1 CARTON (45802-138-35) > 15 g in 1 TUBE
45802- Perrigo New York Inc
45802-141- Ciclopirox
45802-141-67- 1 BOTTLE, WITH APPLICATOR in 1 CARTON (45802-141-67) > 6.6 mL in 1 BOTTLE, WITH APPLICATOR
45802- Perrigo New York Inc
45802-400- Ciclopirox Olamine
45802-400-46- 1 BOTTLE in 1 CARTON (45802-400-46) > 60 mL in 1 BOTTLE
45802- Perrigo New York Inc
45802-400- Ciclopirox Olamine
45802-400-49- 1 BOTTLE in 1 CARTON (45802-400-49) > 30 mL in 1 BOTTLE
45802- Perrigo New York Inc
45802-401- Ciclopirox
45802-401-09- 1 BOTTLE in 1 CARTON (45802-401-09) > 120 mL in 1 BOTTLE
47781- Alvogen Inc.
47781-530- Ciclopirox
47781-530-73- 1 TUBE in 1 CARTON (47781-530-73) > 30 g in 1 TUBE
47781- Alvogen Inc.
47781-530- Ciclopirox
47781-530-84- 1 TUBE in 1 CARTON (47781-530-84) > 45 g in 1 TUBE
47781- Alvogen Inc.
47781-530- Ciclopirox
47781-530-85- 1 TUBE in 1 CARTON (47781-530-85) > 100 g in 1 TUBE
50383- Hi-Tech Pharmacal Co., Inc.
50383-419- Ciclopirox
50383-419-03- 1 BOTTLE in 1 CARTON (50383-419-03) > 3.3 mL in 1 BOTTLE
50383- Hi-Tech Pharmacal Co., Inc.
50383-419- Ciclopirox
50383-419-06- 1 BOTTLE in 1 CARTON (50383-419-06) > 6.6 mL in 1 BOTTLE
51672- Taro Pharmaceuticals U.S.A., Inc.
51672-1318- Ciclopirox Olamine
51672-1318-1- 1 TUBE in 1 CARTON (51672-1318-1) > 15 g in 1 TUBE
51672- Taro Pharmaceuticals U.S.A., Inc.
51672-1318- Ciclopirox Olamine
51672-1318-2- 1 TUBE in 1 CARTON (51672-1318-2) > 30 g in 1 TUBE
51672- Taro Pharmaceuticals U.S.A., Inc.
51672-1318- Ciclopirox Olamine
51672-1318-8- 1 TUBE in 1 CARTON (51672-1318-8) > 90 g in 1 TUBE
51672- Taro Pharmaceuticals U.S.A., Inc.
51672-1323- Ciclopirox
51672-1323-3- 1 BOTTLE in 1 CARTON (51672-1323-3) > 30 mL in 1 BOTTLE
51672- Taro Pharmaceuticals U.S.A., Inc.
51672-1323- Ciclopirox
51672-1323-4- 1 BOTTLE in 1 CARTON (51672-1323-4) > 60 mL in 1 BOTTLE
51672- Taro Pharmaceuticals U.S.A., Inc.
51672-1351- Ciclopirox
51672-1351-8- 1 BOTTLE, PLASTIC in 1 CARTON (51672-1351-8) > 120 mL in 1 BOTTLE, PLASTIC
51672- Taro Pharmaceuticals U.S.A., Inc.
51672-5302- Ciclopirox
51672-5302-0- 1 BOTTLE, WITH APPLICATOR in 1 CARTON (51672-5302-0) > 6.6 mL in 1 BOTTLE, WITH APPLICATOR
52565- Teligent Pharma, Inc.
52565-032- Ciclopirox
52565-032-12- 1 BOTTLE, PLASTIC in 1 CARTON (52565-032-12) > 120 mL in 1 BOTTLE, PLASTIC
