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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash

GI: ↑liver enzymes, cholecystitis, cholelithiasis, nausea, pancreatitis

MS: myopathy, RHABDOMYOLYSIS

Misc: ANGIOEDEMA

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Renal Impairment

US Brand Names ⬆ ⬇

Zetia

Action ⬆ ⬇

  • Inhibits absorption of cholesterol in the small intestine.
Therapeutic effects:
  • Reduction of LDL-C concentrations.
  • Reduction of sitosterol and campesterol concentrations.

Classifications ⬆ ⬇

Therapeutic Classification: lipid-lowering agents

Pharmacologic Classification: cholesterol absorption inhibitors

Pharmacokinetics ⬆ ⬇

Absorption: Following absorption, rapidly converted to ezetimibe-glucuronide, which is active. Bioavailability is variable.

Distribution: Unknown.

Metabolism/Excretion: Undergoes enterohepatic recycling, mostly eliminated in feces, minimal renal excretion.

Half-Life: 22 hr.

Canadian Brand Names ⬆ ⬇

Ezetrol

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
POunknownunknownunknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

e-ZET-i-mibe

Pill Image

ezetimibe_195-8834.jpg

Code ⬆

NDC Code