- IV (Adults ): Day 1: 85 mg/m2 with leucovorin 200 mg/m2 at the same time over 2 hr, followed by 5-fluorouracil 400 mg/m2 bolus over 2–4 min, then 5-fluorouracil 600 mg/m2 as a 22-hr infusion. Day 2: leucovorin 200 mg/m2 over 2 hr, followed by 5-fluorouracil 400 mg/m2 bolus over 2–4 min, then 5-fluorouracil 600 mg/m2 as a 22-hr infusion. Cycle is repeated every 2 wk. Dosage reduction/alteration may be required for neurotoxicity or other serious adverse effects.
Renal Impairment
- IV (Adults ): CCr <30 mL/min:↓ dose on Day 1 to 65 mg/m2.
