vancomycin

section name header

Indications ⬇

REMS

IV: Potentially life-threatening infections when less toxic anti-infectives are contraindicated. Particularly useful in staphylococcal infections, including:
- endocarditis,
- meningitis,
- osteomyelitis,
- pneumonia,
- septicemia,
- soft-tissue infections in patients who have allergies to penicillin or its derivatives or when sensitivity testing demonstrates resistance to methicillin.
PO: Staphylococcal enterocolitis or diarrhea due to Clostridioides difficile.
IV: Part of endocarditis prophylaxis in high-risk patients who are allergic to penicillin.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity.

Use Cautiously in:

Renal impairment (dose ↓ required if CCr ≤80 mL/min);
Hearing impairment;
Intestinal obstruction or inflammation (↑ systemic absorption when given orally);
OB: Pharmacokinetics of IV vancomycin may be altered in pregnancy (volume of distribution may be ↑); systemic absorption of PO vancomycin expected to be minimal;
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant.

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypotension

Derm: ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS, LINEAR IGA BULLOUS DERMATOSIS, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS

EENT: ototoxicity

GI: nausea, vomiting

GU: nephrotoxicity

Hemat: eosinophilia, leukopenia

Local: phlebitis

MS: back and neck pain

Misc: chills, fever, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), vancomycin flushing syndrome (with rapid infusion)

Interactions ⬆ ⬇

Drug-drug:

May cause additive ototoxicity and nephrotoxicity with other ototoxic and nephrotoxic drugs, including aspirin, aminoglycosides, cyclosporine, cisplatin, and loop diuretics.
May enhance neuromuscular blockade from nondepolarizing neuromuscular blocking agents.
↑risk of histamine flush when used with general anesthetics in children.

Availability ⬆ ⬇

(Generic available)

Capsules: 125 mg; 250 mg
Powder for oral solutiongrape flavor: 3.75 g/bottle; 7.5 g/bottle; 15 g/bottle
Premixed infusion: 500 mg/100 mL D5W; 750 mg/150 mL D5W; 1000 mg/200 mL D5W or 0.9% NaCl; 1250 mg/200 mL D5W; 1500 mg/300 mL D5W; 1750 mg/350 mL D5W; 2000 mg/400 mL D5W
Solution for injection: 250 mg/vial; 500 mg/vial; 750 mg/vial; 1 g/vial; 1.5 g/vial; 5 g/vial; 10 g/vial; 100 g/vial

Route/Dosage ⬆ ⬇

Serious Systemic Infections

IV (Adults ): 500 mg every 6 hr or 1 g every 12 hr (up to 4 g/day).
IV (Children >1 mo): 40 mg/kg/day divided every 6–8 hr. Staphylococcal CNS infection: 60 mg/kg/day divided every 6 hr, maximum dose: 1 g/dose.
IV (Neonates 1 wk–1 mo and >2000 g): 15–20 mg/kg every 8 hr.
IV (Neonates 1 wk–1 mo and 1200–2000 g): 10–15 mg/kg every 8–12 hr.
IV (Neonates 1 wk–1 mo and <1200 g): 15 mg/kg every 24 hr.
IV (Neonates <1 wk and >2000 g): 10–15 mg/kg every 8–12 hr.
IV (Neonates <1 wk and 1200–2000 g): 10–15 mg/kg every 12–18 hr.
IV (Neonates <1 wk and <1200 g): 15 mg/kg every 24 hr.
IT (Adults ): 20 mg/day.
IT (Children ): 5–20 mg/day.
IT (Neonates ): 5–10 mg/day.

Renal Impairment

IV (Adults ): An initial loading dose of 750 mg–1 g (not less than 15 mg/kg); serum level monitoring is optimal for choosing maintenance dose in patients with renal impairment; these guidelines may be helpful. CCr 50–80 mL/min: 1 g every 1–3 days; CCr 10–50 mL/min: 1 g every 3–7 days; CCr <10 mL/min: 1 g every 7–14 days.

Endocarditis Prophylaxis in Penicillin-Allergic Patients

IV (Adults and Adolescents): 1 g single dose 1 hr preprocedure.
IV (Children ): 20 mg/kg single dose 1 hr preprocedure.

Diarrhea Due to C. difficile

PO (Adults ): 125 mg every 6 hr for 10 days.
PO (Children ): 40 mg/kg/day divided into 3 or 4 doses for 7–10 days (not to exceed 2 g/day).

Staphylococcal Enterocolitis

PO (Adults ): 500–2000 mg/day in 3–4 divided doses for 7–10 days.
PO (Children ): 40 mg/kg/day in 3–4 divided doses for 7–10 days (not to exceed 2 g/day).

US Brand Names ⬆ ⬇

Firvanq, Vancocin

Action ⬆ ⬇

Binds to bacterial cell wall, resulting in cell death.

Therapeutic effects:

Bactericidal action against susceptible organisms.

Spectrum:

Active against gram-positive pathogens, including:
- Staphylococci (including methicillin-resistant strains of Staphylococcus aureus),
- Group A beta-hemolytic streptococci,
- Streptococcus pneumoniae,
- Corynebacterium,
- Clostridioides difficile,
- Enterococcus faecalis,
- Enterococcus faecium.

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives

Pharmacokinetics ⬆ ⬇

Absorption: Poorly absorbed from the GI tract.

Distribution: Widely distributed to tissues. Some penetration (20–30%) of CSF.

Metabolism/Excretion: Oral doses excreted primarily in the feces; IV vancomycin eliminated almost entirely by the kidneys.

Half-Life: Neonates: 6–10 hr; Children 3 mo–3 yr: 4 hr; Children >3 yr: 2–2.3 hr; Adults: 5–8 hr (↑ in renal impairment).

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
IV	rapid	end of infusion	12–24 hr

Patient/Family Teaching ⬆ ⬇

Advise patients on oral vancomycin to take as directed. Take missed doses as soon as remembered unless almost time for next dose; do not double dose.
Instruct patient to report signs of hypersensitivity, tinnitus, vertigo, or hearing loss.
Advise patient to notify health care professional if no improvement is seen in a few days.
Patients with a history of rheumatic heart disease or valve replacement need to be taught importance of using antimicrobial prophylaxis prior to invasive dental or medical procedures.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Pronunciation ⬆ ⬇

van-koe-MYE-sin

Code ⬆

NDC Code

0121- Pharmaceutical Associates, Inc.
- 0121-0867- VANCOMYCIN HYDROCHLORIDE
  - 0121-0867-20- 2 BLISTER PACK in 1 CARTON (0121-0867-20) > 10 CAPSULE in 1 BLISTER PACK

0121- Pharmaceutical Associates, Inc.
- 0121-0890- VANCOMYCIN HYDROCHLORIDE
  - 0121-0890-20- 2 BLISTER PACK in 1 CARTON (0121-0890-20) > 10 CAPSULE in 1 BLISTER PACK

0143- West-Ward Pharmaceuticals Corp
- 0143-9355- Vancomycin Hydrochloride
  - 0143-9355-10- 10 VIAL in 1 CARTON (0143-9355-10) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL (0143-9355-01)

0143- West-Ward Pharmaceuticals Corp
- 0143-9358- Vancomycin Hydrochloride
  - 0143-9358-01- 1 INJECTION, POWDER, FOR SOLUTION in 1 CARTON (0143-9358-01)

0143- West-Ward Pharmaceuticals Corp
- 0143-9359- Vancomycin Hydrochloride
  - 0143-9359-01- 1 INJECTION, POWDER, FOR SOLUTION in 1 BOTTLE (0143-9359-01)

0338- Baxter Healthcare Corporation
- 0338-3551- VANCOMYCIN HYDROCHLORIDE
  - 0338-3551-48- 100 mL in 1 BAG (0338-3551-48)

0338- Baxter Healthcare Corporation
- 0338-3552- VANCOMYCIN HYDROCHLORIDE
  - 0338-3552-48- 200 mL in 1 BAG (0338-3552-48)

0338- Baxter Healthcare Corporation
- 0338-3580- VANCOMYCIN HYDROCHLORIDE
  - 0338-3580-48- 200 mL in 1 BAG (0338-3580-48)

0338- Baxter Healthcare Corporation
- 0338-3581- VANCOMYCIN HYDROCHLORIDE
  - 0338-3581-01- 100 mL in 1 BAG (0338-3581-01)

0338- Baxter Healthcare Corporation
- 0338-3582- VANCOMYCIN HYDROCHLORIDE
  - 0338-3582-01- 150 mL in 1 BAG (0338-3582-01)

0338- Baxter Healthcare Corporation
- 0338-3583- VANCOMYCIN HYDROCHLORIDE
  - 0338-3583-01- 200 mL in 1 BAG (0338-3583-01)

0409- Hospira, Inc.
- 0409-4332- Vancomycin Hydrochloride
  - 0409-4332-01- 10 VIAL in 1 TRAY (0409-4332-01) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL (0409-4332-11)

0409- Hospira, Inc.
- 0409-6509- Vancomycin Hydrochloride
  - 0409-6509-01- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (0409-6509-01) > 100 mL in 1 VIAL, PHARMACY BULK PACKAGE

0409- Hospira, Inc.
- 0409-6509- Vancomycin Hydrochloride
  - 0409-6509-49- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (0409-6509-49) > 100 mL in 1 VIAL, PHARMACY BULK PACKAGE

0409- Hospira, Inc.
- 0409-6510- Vancomycin Hydrochloride
  - 0409-6510-01- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (0409-6510-01) > 100 mL in 1 VIAL, PHARMACY BULK PACKAGE

0409- Hospira, Inc.
- 0409-6531- Vancomycin Hydrochloride
  - 0409-6531-01- 10 VIAL, SINGLE-DOSE in 1 TRAY (0409-6531-01) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL, SINGLE-DOSE (0409-6531-11)

0409- Hospira, Inc.
- 0409-6531- Vancomycin Hydrochloride
  - 0409-6531-02- 10 VIAL in 1 TRAY (0409-6531-02) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL (0409-6531-12)

0409- Hospira, Inc.
- 0409-6533- Vancomycin Hydrochloride
  - 0409-6533-01- 10 VIAL in 1 TRAY (0409-6533-01) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL (0409-6533-11)

0409- Hospira, Inc.
- 0409-6534- Vancomycin Hydrochloride
  - 0409-6534-01- 10 VIAL, SINGLE-DOSE in 1 TRAY (0409-6534-01) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL, SINGLE-DOSE (0409-6534-11)

0409- Hospira, Inc.
- 0409-6535- Vancomycin Hydrochloride
  - 0409-6535-01- 10 VIAL, SINGLE-DOSE in 1 TRAY (0409-6535-01) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL, SINGLE-DOSE (0409-6535-11)

0781- Sandoz Inc
- 0781-3187- Vancomycin Hydrochloride
  - 0781-3187-95- 10 VIAL in 1 CARTON (0781-3187-95) > 10 mL in 1 VIAL (0781-3187-70)

0781- Sandoz Inc
- 0781-3188- Vancomycin Hydrochloride
  - 0781-3188-95- 10 VIAL in 1 CARTON (0781-3188-95) > 20 mL in 1 VIAL (0781-3188-80)

17478- Akorn, Inc.
- 17478-741- Vancomycin Hydrochloride
  - 17478-741-02- 2 BLISTER PACK in 1 CARTON (17478-741-02) > 10 CAPSULE in 1 BLISTER PACK

17478- Akorn, Inc.
- 17478-742- Vancomycin Hydrochloride
  - 17478-742-02- 2 BLISTER PACK in 1 CARTON (17478-742-02) > 10 CAPSULE in 1 BLISTER PACK

23155- Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
- 23155-217- VANCOMYCIN HYDROCHLORIDE
  - 23155-217-31- 1 VIAL, GLASS in 1 CARTON (23155-217-31) > 4 mL in 1 VIAL, GLASS

23155- Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
- 23155-217- VANCOMYCIN HYDROCHLORIDE
  - 23155-217-41- 10 VIAL, GLASS in 1 CARTON (23155-217-41) > 4 mL in 1 VIAL, GLASS

23155- Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
- 23155-217- VANCOMYCIN HYDROCHLORIDE
  - 23155-217-42- 25 VIAL, GLASS in 1 CARTON (23155-217-42) > 4 mL in 1 VIAL, GLASS

23155- Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
- 23155-218- VANCOMYCIN HYDROCHLORIDE
  - 23155-218-41- 10 VIAL, GLASS in 1 CARTON (23155-218-41) > 8 mL in 1 VIAL, GLASS

23155- Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
- 23155-219- VANCOMYCIN HYDROCHLORIDE
  - 23155-219-31- 100 mL in 1 VIAL, GLASS (23155-219-31)

25021- Sagent Pharmaceuticals
- 25021-157- Vancomycin
  - 25021-157-99- 1 BOTTLE in 1 CARTON (25021-157-99) > 100 mL in 1 BOTTLE

25021- Sagent Pharmaceuticals
- 25021-158- Vancomycin
  - 25021-158-99- 1 BOTTLE in 1 CARTON (25021-158-99) > 100 mL in 1 BOTTLE

45932- Xellia Pharmaceuticals, ApS
- 45932-0028- Vancomycin Hydrochloride
  - 45932-0028-1- 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 CARTON (45932-0028-1)

45932- Xellia Pharmaceuticals, ApS
- 45932-0028- Vancomycin Hydrochloride
  - 45932-0028-2- 10 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 CARTON (45932-0028-2)

45932- Xellia Pharmaceuticals, ApS
- 45932-0029- Vancomycin Hydrochloride
  - 45932-0029-1- 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 CARTON (45932-0029-1)

45932- Xellia Pharmaceuticals, ApS
- 45932-0029- Vancomycin Hydrochloride
  - 45932-0029-2- 10 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 CARTON (45932-0029-2)

45932- Xellia Pharmaceuticals ApS
- 45932-0031- Vancomycin Hydrochloride
  - 45932-0031-1- 1 BOTTLE in 1 CARTON (45932-0031-1) > 100 mL in 1 BOTTLE

45932- Xellia Pharmaceuticals ApS
- 45932-0032- Vancomycin Hydrochloride
  - 45932-0032-1- 1 BOTTLE in 1 CARTON (45932-0032-1) > 100 mL in 1 BOTTLE

47781- Alvogen Inc.
- 47781-597- Vancomycin Hydrochloride
  - 47781-597-91- 10 VIAL in 1 CARTON (47781-597-91) > 20 mL in 1 VIAL (47781-597-07)

47781- Alvogen Inc.
- 47781-598- Vancomycin Hydrochloride
  - 47781-598-91- 10 VIAL in 1 CARTON (47781-598-91) > 10 mL in 1 VIAL (47781-598-07)

47781- Alvogen Inc.
- 47781-729- vancomycin hydrochloride
  - 47781-729-01- 100 CAPSULE in 1 BOTTLE (47781-729-01)

47781- Alvogen Inc.
- 47781-729- vancomycin hydrochloride
  - 47781-729-02- 2 BLISTER PACK in 1 CARTON (47781-729-02) > 10 CAPSULE in 1 BLISTER PACK

47781- Alvogen Inc.
- 47781-729- vancomycin hydrochloride
  - 47781-729-50- 50 CAPSULE in 1 BOTTLE (47781-729-50)

47781- Alvogen Inc.
- 47781-730- vancomycin hydrochloride
  - 47781-730-01- 100 CAPSULE in 1 BOTTLE (47781-730-01)

47781- Alvogen Inc.
- 47781-730- vancomycin hydrochloride
  - 47781-730-02- 2 BLISTER PACK in 1 CARTON (47781-730-02) > 10 CAPSULE in 1 BLISTER PACK

47781- Alvogen Inc.
- 47781-730- vancomycin hydrochloride
  - 47781-730-50- 50 CAPSULE in 1 BOTTLE (47781-730-50)

51991- Breckenridge Pharmaceutical, Inc.
- 51991-940- Vancomycin Hydrochloride
  - 51991-940-17- 10 VIAL, SINGLE-USE in 1 CARTON (51991-940-17) > 1 INJECTION, SOLUTION in 1 VIAL, SINGLE-USE (51991-940-99)

51991- Breckenridge Pharmaceutical, Inc.
- 51991-941- Vancomycin Hydrochloride
  - 51991-941-17- 10 VIAL, MULTI-DOSE in 1 CARTON (51991-941-17) > 1 INJECTION, SOLUTION in 1 VIAL, MULTI-DOSE (51991-941-99)

52584- General Injectables and Vaccines, Inc
- 52584-332- Vancomycin Hydrochloride
  - 52584-332-01- 1 VIAL in 1 BAG (52584-332-01) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL

55150- AuroMedics Pharma LLC
- 55150-203- Vancomycin Hydrochloride
  - 55150-203-10- 10 VIAL in 1 CARTON (55150-203-10) > 10 mL in 1 VIAL

55150- AuroMedics Pharma LLC
- 55150-204- Vancomycin Hydrochloride
  - 55150-204-20- 10 VIAL in 1 CARTON (55150-204-20) > 20 mL in 1 VIAL

55150- AuroMedics Pharma LLC
- 55150-205- Vancomycin Hydrochloride
  - 55150-205-99- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (55150-205-99) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL, PHARMACY BULK PACKAGE

55150- AuroMedics Pharma LLC
- 55150-206- Vancomycin Hydrochloride
  - 55150-206-99- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (55150-206-99) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL, PHARMACY BULK PACKAGE

62559- ANI Pharmaceuticals, Inc.
- 62559-310- Vancocin
  - 62559-310-20- 2 BLISTER PACK in 1 CARTON (62559-310-20) > 10 CAPSULE in 1 BLISTER PACK

62559- ANI Pharmaceuticals, Inc.
- 62559-311- Vancocin
  - 62559-311-20- 2 BLISTER PACK in 1 CARTON (62559-311-20) > 10 CAPSULE in 1 BLISTER PACK

62559- ANI Pharmaceuticals, Inc.
- 62559-390- vancomycin hydrochloride
  - 62559-390-20- 2 BLISTER PACK in 1 CARTON (62559-390-20) > 10 CAPSULE in 1 BLISTER PACK

62559- ANI Pharmaceuticals, Inc.
- 62559-390- vancomycin hydrochloride
  - 62559-390-50- 50 CAPSULE in 1 BOTTLE (62559-390-50)

62559- ANI Pharmaceuticals, Inc.
- 62559-391- vancomycin hydrochloride
  - 62559-391-20- 2 BLISTER PACK in 1 CARTON (62559-391-20) > 10 CAPSULE in 1 BLISTER PACK

62559- ANI Pharmaceuticals, Inc.
- 62559-391- vancomycin hydrochloride
  - 62559-391-50- 50 CAPSULE in 1 BOTTLE (62559-391-50)

62559- ANI Pharmaceuticals, Inc.
- 62559-830- Vancomycin Hydrochloride
  - 62559-830-03- 300 mL in 1 BOTTLE, PLASTIC (62559-830-03)

62559- ANI Pharmaceuticals, Inc.
- 62559-830- Vancomycin Hydrochloride
  - 62559-830-55- 150 mL in 1 BOTTLE, PLASTIC (62559-830-55)

62559- ANI Pharmaceuticals, Inc.
- 62559-830- Vancomycin Hydrochloride
  - 62559-830-80- 80 mL in 1 BOTTLE, PLASTIC (62559-830-80)

63323- Fresenius Kabi USA, LLC
- 63323-203- Vancomycin Hydrochloride
  - 63323-203-20- 10 VIAL in 1 TRAY (63323-203-20) > 15 mL in 1 VIAL (63323-203-01)

63323- Fresenius Kabi USA, LLC
- 63323-203- Vancomycin Hydrochloride
  - 63323-203-26- 10 VIAL in 1 TRAY (63323-203-26) > 15 mL in 1 VIAL (63323-203-41)

63323- Fresenius Kabi, LLC
- 63323-221- Vancomycin Hydrochloride
  - 63323-221-38- 25 VIAL in 1 TRAY (63323-221-38) > 10 mL in 1 VIAL (63323-221-33)

63323- Fresenius Kabi, LLC
- 63323-221- Vancomycin Hydrochloride
  - 63323-221-48- 25 VIAL in 1 TRAY (63323-221-48) > 10 mL in 1 VIAL (63323-221-43)

63323- Fresenius Kabi, LLC
- 63323-284- Vancomycin Hydrochloride
  - 63323-284-20- 10 VIAL in 1 TRAY (63323-284-20) > 20 mL in 1 VIAL (63323-284-01)

63323- Fresenius Kabi, LLC
- 63323-284- Vancomycin Hydrochloride
  - 63323-284-21- 10 VIAL in 1 TRAY (63323-284-21) > 20 mL in 1 VIAL

63323- Fresenius Kabi, LLC
- 63323-284- Vancomycin Hydrochloride
  - 63323-284-45- 10 VIAL in 1 TRAY (63323-284-45) > 20 mL in 1 VIAL (63323-284-41)

63323- Fresenius Kabi USA, LLC
- 63323-295- Vancomycin Hydrochloride
  - 63323-295-61- 1 BOTTLE in 1 CARTON (63323-295-61) > 100 mL in 1 BOTTLE

63323- Fresenius Kabi USA, LLC
- 63323-295- Vancomycin Hydrochloride
  - 63323-295-66- 1 BOTTLE in 1 CARTON (63323-295-66) > 100 mL in 1 BOTTLE

63323- Fresenius Kabi USA, LLC
- 63323-314- Vancomycin Hydrochloride
  - 63323-314-61- 1 BOTTLE in 1 CARTON (63323-314-61) > 100 mL in 1 BOTTLE

63323- Fresenius Kabi USA, LLC
- 63323-314- Vancomycin Hydrochloride
  - 63323-314-66- 1 BOTTLE in 1 CARTON (63323-314-66) > 100 mL in 1 BOTTLE

63323- Fresenius Kabi USA, LLC
- 63323-314- Vancomycin Hydrochloride
  - 63323-314-68- 1 BOTTLE in 1 CARTON (63323-314-68) > 100 mL in 1 BOTTLE

65628- CutisPharma, Inc.
- 65628-204- FIRVANQ
  - 65628-204-05- 1 KIT in 1 CARTON (65628-204-05) * 3.75 g in 1 BOTTLE * 147 mL in 1 BOTTLE

65628- CutisPharma, Inc.
- 65628-205- FIRVANQ
  - 65628-205-10- 1 KIT in 1 CARTON (65628-205-10) * 7.5 g in 1 BOTTLE * 295 mL in 1 BOTTLE

65628- CutisPharma, Inc.
- 65628-206- FIRVANQ
  - 65628-206-05- 1 KIT in 1 CARTON (65628-206-05) * 7.5 g in 1 BOTTLE * 145 mL in 1 BOTTLE

65628- CutisPharma, Inc.
- 65628-208- FIRVANQ
  - 65628-208-10- 1 KIT in 1 CARTON (65628-208-10) * 15 g in 1 BOTTLE * 289 mL in 1 BOTTLE

66288- SAMSON MEDICAL TECHNOLOGIES LLC
- 66288-7100- Vancomycin Hydrochloride
  - 66288-7100-1- 1 BAG in 1 BAG (66288-7100-1) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 BAG

67457- Mylan Institutional LLC
- 67457-339- Vancomycin Hydrochloride
  - 67457-339-50- 10 VIAL in 1 CARTON (67457-339-50) > 10 mL in 1 VIAL (67457-339-00)

67457- Mylan Institutional LLC
- 67457-340- Vancomycin Hydrochloride
  - 67457-340-01- 10 VIAL in 1 CARTON (67457-340-01) > 20 mL in 1 VIAL (67457-340-00)

67457- Mylan Institutional LLC
- 67457-341- vancomycin hydrochloride
  - 67457-341-05- 1 VIAL in 1 CARTON (67457-341-05) > 100 mL in 1 VIAL

67457- Mylan Institutional LLC
- 67457-342- Vancomycin Hydrochloride
  - 67457-342-10- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (67457-342-10) > 100 mL in 1 VIAL, PHARMACY BULK PACKAGE

67457- Mylan Institutional LLC
- 67457-611- vancomycin hydrochloride
  - 67457-611-10- 10 VIAL in 1 CARTON (67457-611-10) > 10 mL in 1 VIAL

67457- Mylan Institutional LLC
- 67457-612- vancomycin hydrochloride
  - 67457-612-20- 10 VIAL in 1 CARTON (67457-612-20) > 20 mL in 1 VIAL

67457- Mylan Institutional LLC
- 67457-613- Vancomycin Hydrochloride
  - 67457-613-10- 1 VIAL in 1 CARTON (67457-613-10) > 100 mL in 1 VIAL

67457- Mylan Institutional LLC
- 67457-614- Vancomycin hydrochloride
  - 67457-614-10- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (67457-614-10) > 100 mL in 1 VIAL, PHARMACY BULK PACKAGE

67457- Mylan Institutional LLC
- 67457-705- Vancomycin Hydrochloride
  - 67457-705-75- 10 VIAL, SINGLE-DOSE in 1 CARTON (67457-705-75) > 15 mL in 1 VIAL, SINGLE-DOSE (67457-705-00)

67457- Mylan Institutional LLC
- 67457-822- Vancomycin Hydrochloride
  - 67457-822-99- 10 VIAL, SINGLE-DOSE in 1 CARTON (67457-822-99) > 5 mL in 1 VIAL, SINGLE-DOSE (67457-822-25)

67457- Mylan Institutional LLC
- 67457-823- Vancomycin Hydrochloride
  - 67457-823-99- 10 VIAL, SINGLE-DOSE in 1 CARTON (67457-823-99) > 25 mL in 1 VIAL, SINGLE-DOSE (67457-823-12)

67457- Mylan Institutional LLC
- 67457-824- Vancomycin Hydrochloride
  - 67457-824-99- 10 VIAL, SINGLE-DOSE in 1 CARTON (67457-824-99) > 30 mL in 1 VIAL, SINGLE-DOSE (67457-824-15)

68001- BluePoint Laboratories
- 68001-338- Vancomycin Hydrochloride
  - 68001-338-62- 10 VIAL, SINGLE-USE in 1 CARTON (68001-338-62) > 1 INJECTION, SOLUTION in 1 VIAL, SINGLE-USE (68001-338-61)

68001- BluePoint Laboratories
- 68001-339- Vancomycin Hydrochloride
  - 68001-339-64- 10 VIAL, MULTI-DOSE in 1 CARTON (68001-339-64) > 1 INJECTION, SOLUTION in 1 VIAL, MULTI-DOSE (68001-339-63)

68001- BluePoint Laboratories
- 68001-406- Vancomycin Hydrochloride
  - 68001-406-73- 1 VIAL, GLASS in 1 CARTON (68001-406-73) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL, GLASS

68001- BluePoint Laboratories
- 68001-407- Vancomycin Hydrochloride
  - 68001-407-75- 1 VIAL, GLASS in 1 CARTON (68001-407-75) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL, GLASS

68083- Gland Pharma Limited
- 68083-143- Vancomycin Hydrochloride
  - 68083-143-25- 25 VIAL in 1 CARTON (68083-143-25) > 10 mL in 1 VIAL

68083- Gland Pharma Limited
- 68083-144- Vancomycin Hydrochloride
  - 68083-144-10- 10 VIAL in 1 CARTON (68083-144-10) > 20 mL in 1 VIAL

68180- Lupin Pharmaceuticals, Inc.
- 68180-166- VANCOMYCIN HYDROCHLORIDE
  - 68180-166-13- 2 BLISTER PACK in 1 CARTON (68180-166-13) > 10 CAPSULE in 1 BLISTER PACK (68180-166-11)

68180- Lupin Pharmaceuticals, Inc.
- 68180-167- VANCOMYCIN HYDROCHLORIDE
  - 68180-167-13- 2 BLISTER PACK in 1 CARTON (68180-167-13) > 10 CAPSULE in 1 BLISTER PACK (68180-167-11)

70436- Slate Run Pharmaceuticals, LLC
- 70436-020- VANCOMYCIN HYDROCHLORIDE
  - 70436-020-82- 10 VIAL in 1 CARTON (70436-020-82) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL

70436- Slate Run Pharmaceuticals, LLC
- 70436-021- VANCOMYCIN HYDROCHLORIDE
  - 70436-021-82- 10 VIAL in 1 CARTON (70436-021-82) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL

70594- Xellia Pharmaceuticals USA LLC
- 70594-041- Vancomycin
  - 70594-041-02- 6 BAG in 1 CARTON (70594-041-02) > 100 mL in 1 BAG (70594-041-01)

70594- Xellia Pharmaceuticals USA LLC
- 70594-041- Vancomycin
  - 70594-041-03- 12 BAG in 1 CARTON (70594-041-03) > 100 mL in 1 BAG (70594-041-01)

70594- Xellia Pharmaceuticals USA LLC
- 70594-042- Vancomycin
  - 70594-042-02- 6 BAG in 1 CARTON (70594-042-02) > 200 mL in 1 BAG (70594-042-01)

70594- Xellia Pharmaceuticals USA LLC
- 70594-042- Vancomycin
  - 70594-042-03- 12 BAG in 1 CARTON (70594-042-03) > 200 mL in 1 BAG (70594-042-01)

70594- Xellia Pharmaceuticals USA LLC
- 70594-043- Vancomycin
  - 70594-043-02- 6 BAG in 1 CARTON (70594-043-02) > 300 mL in 1 BAG (70594-043-01)

70594- Xellia Pharmaceuticals USA LLC
- 70594-044- Vancomycin
  - 70594-044-02- 6 BAG in 1 CARTON (70594-044-02) > 400 mL in 1 BAG (70594-044-01)

70594- Xellia Pharmaceuticals USA LLC
- 70594-045- Vancomycin Hydrochloride
  - 70594-045-02- 10 VIAL, GLASS in 1 CARTON (70594-045-02) > 1 INJECTION, POWDER, FOR SOLUTION in 1 VIAL, GLASS (70594-045-01)

70594- Xellia Pharmaceuticals USA LLC
- 70594-045- Vancomycin Hydrochloride
  - 70594-045-03- 25 VIAL, GLASS in 1 CARTON (70594-045-03) > 1 INJECTION, POWDER, FOR SOLUTION in 1 VIAL, GLASS (70594-045-01)

70594- Xellia Pharmaceuticals USA LLC
- 70594-046- Vancomycin Hydrochloride
  - 70594-046-02- 10 VIAL, GLASS in 1 CARTON (70594-046-02) > 1 INJECTION, POWDER, FOR SOLUTION in 1 VIAL, GLASS (70594-046-01)

70594- Xellia Pharmaceuticals USA LLC
- 70594-047- Vancomycin Hydrochloride
  - 70594-047-01- 1 VIAL, GLASS in 1 CARTON (70594-047-01) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL, GLASS

70594- Xellia Pharmaceuticals USA LLC
- 70594-048- Vancomycin Hydrochloride
  - 70594-048-01- 1 VIAL, GLASS in 1 CARTON (70594-048-01) > 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL, GLASS

70860- Athenex Pharmaceutical Division, LLC.
- 70860-104- Vancomycin Hydrochloride
  - 70860-104-10- 10 VIAL in 1 CARTON (70860-104-10) > 10 mL in 1 VIAL (70860-104-41)

70860- Athenex Pharmaceutical Division, LLC.
- 70860-105- Vancomycin Hydrochloride
  - 70860-105-20- 10 VIAL in 1 CARTON (70860-105-20) > 20 mL in 1 VIAL (70860-105-41)

72572- Civica, Inc.
- 72572-801- Vancomycin Hydrochloride
  - 72572-801-02- 10 VIAL, GLASS in 1 CARTON (72572-801-02) > 10 mL in 1 VIAL, GLASS (72572-801-01)

72572- Civica, Inc.
- 72572-803- Vancomycin Hydrochloride
  - 72572-803-01- 1 BOTTLE in 1 CARTON (72572-803-01) > 100 mL in 1 BOTTLE

72572- Civica, Inc.
- 72572-805- Vancomycin Hydrochloride
  - 72572-805-01- 1 BOTTLE in 1 CARTON (72572-805-01) > 100 mL in 1 BOTTLE

76333- Orient Pharma Co.,Ltd
- 76333-264- VANCOMYCIN HYDROCHLORIDE
  - 76333-264-01- 2 BLISTER PACK in 1 CARTON (76333-264-01) > 10 CAPSULE in 1 BLISTER PACK (76333-264-26)

76333- Orient Pharma Co.,Ltd
- 76333-265- VANCOMYCIN HYDROCHLORIDE
  - 76333-265-02- 2 BLISTER PACK in 1 CARTON (76333-265-02) > 10 CAPSULE in 1 BLISTER PACK (76333-265-26)

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