iloprost

Contraindicated in:

Hypersensitivity;
Systolic BP <85 mm Hg;
Lactation: Lactation.

Use Cautiously in:

Concurrent use of drugs or coexisting medical conditions that may ↑ risk of syncope;
COPD, asthma, or acute pulmonary infection (may ↑ risk of bronchospasm);
Hepatic impairment (may need to ↑ dosing interval);
OB: Use during pregnancy only if potential maternal benefit justifies potential fetal risk;
Pedi: Safety and effectiveness not established in children.

Adv. Reactions/Side Effects ⬆ ⬇

CV: vasodilation, HF, chest pain, hypotension, peripheral edema, supraventricular tachycardia

Derm: facial flushing

EENT: epistaxis

GI: diarrhea, gingival bleeding, nausea, vomiting

GU: renal failure

MS: back pain, jaw-muscle spasm, muscle cramps

Neuro: dizziness, fainting, headache, insomnia

Resp: cough, bronchospasm, dyspnea, hemoptysis, wheezing

Interactions ⬆ ⬇

Drug-drug:

↑risk of hypotension with other vasodilatorsor diuretics.
Risk of bleeding may be ↑ by anticoagulants.

Availability ⬆ ⬇

Solution for inhalation: 10 mcg/mL; 20 mcg/mL

Route/Dosage ⬆ ⬇

Inhaln (Adults ): 2.5 mcg initially, then 5 mcg/dose 6–9 times daily; not more than every 2 hr.

Hepatic Impairment

Inhaln (Adults ): Child Pugh Class B or C: Consider ↑ dosing interval to every 3–4 hr.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Dilates pulmonary and arterial vasculature.

Therapeutic effects:

Improved exercise capacity.

Classifications ⬆ ⬇

Therapeutic Classification: vasodilators

Pharmacologic Classification: prostacyclins

Pharmacokinetics ⬆ ⬇

Absorption: Unknown.

Distribution: Unknown.

Metabolism/Excretion: Any absorbed iloprost is metabolized.

Half-Life: 20–30 min (plasma).

Time/Action Profile ⬆ ⬇

(improved exercise capacity)

ROUTE	ONSET	PEAK	DURATION
Inhaln	unknown	unknown	up to 2 hr

Patient/Family Teaching ⬆ ⬇

Instruct patient in use of iloprost and I-neb ADD system, frequency, ampule dispensing, and cleaning of equipment. See manufacturer's instructions. Advise patient that inhalation intervals should not be less than 2 hr, but acute benefits of medication may not last 2 hr.
May cause dizziness and fainting due to hypotension. Caution patient to change positions slowly to minimize orthostatic hypotension.
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected and to avoid breastfeeding during therapy.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

66215- Actelion Pharmaceuticals US, Inc.
- 66215-302- Ventavis
  - 66215-302-30- 30 AMPULE in 1 CARTON (66215-302-30) > 1 mL in 1 AMPULE (66215-302-00)

66215- Actelion Pharmaceuticals US, Inc.
- 66215-303- Ventavis
  - 66215-303-30- 30 AMPULE in 1 CARTON (66215-303-30) > 1 mL in 1 AMPULE (66215-303-00)

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Indications ⬇

Contraind./Precautions ⬆ ⬇