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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash, urticaria, angioedema

EENT: intranasalnasal irritation, nasal congestion, sneezing

Neuro: dizziness, headache

Resp: inhalationirritation of the throat and trachea, cough, wheezing, bronchospasm

GI: nausea, unpleasant taste

Misc: ANAPHYLAXIS OR WORSENING OF CONDITIONS BEING TREATEDALLERGIC REACTIONS INCLUDING

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Gastrocrom, NasalCrom

Action ⬆ ⬇

  • Prevents the release of histamine and slow-reacting substance of anaphylaxis (SRS-A) from sensitized mast cells.
Therapeutic effects:
  • Decreased frequency and intensity of asthmatic episodes or allergic reactions.

Classifications ⬆ ⬇

Therapeutic Classification: antiasthmatics, allergy, cold and cough remedies

Pharmacologic Classification: mast cell stabilizers

Pharmacokinetics ⬆ ⬇

Absorption: Oral: 0.5—2 %; Inhalation: Poorly absorbed systemically (total bioavailability is 8%); action is local. Small amounts may reach systemic circulation after inhalation.

Distribution: Because only small amounts are absorbed, distribution is not known.

Metabolism/Excretion: Small amounts absorbed are excreted unchanged in bile and urine.

Half-Life: 80–90 min.

Canadian Brand Names ⬆ ⬇

Apo-Cromolyn

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
Cromolyn-inhalation1–2 wk2–4 wkunknown
Cromolyn-nasal1–2 wk2–4 wkunknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

KROE-moe-lin

Code ⬆

NDC Code