pegvisomant

CV: hypertension, peripheral edema

Derm: lipohypertrophy

Endo: ↑glucose tolerance, growth hormone deficiency

GI: ↑liver enzymes

GU: ↑fertility

MS: back pain

Misc: hypersensitivity reactions (including anaphylaxis and angioedema)

Interactions ⬆ ⬇

Drug-drug:

Patients receiving opioid analgesics often require ↑ doses of pegvisomant to normalize IGF-1.

Availability ⬆ ⬇

Lyophilized powder for injection: 10 mg/vial; 15 mg/vial; 20 mg/vial; 25 mg/vial; 30 mg/vial

Route/Dosage ⬆ ⬇

SC (Adults ): Loading dose: 40 mg; maintenance dose: 10 mg daily, further adjustments in increments/decrements of 5 mg are made based on monitoring of IGF-1 levels (not to exceed 30 mg/day).

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Binds to growth hormone (GH) receptor sites on cell surfaces, blocking the effects of endogenous growth hormone.
Bound to polyethylene glycol (PEG) to reduce clearance and increase duration of action.

Therapeutic effects:

Decreased manifestations of acromegaly and normalized insulin-like growth factor-1 (IGF-1) levels.

Classifications ⬆ ⬇

Therapeutic Classification: hormones

Pharmacologic Classification: growth hormones

Pharmacokinetics ⬆ ⬇

Absorption: 57% absorbed following SUBQ administration.

Distribution: Does not distribute extensively into tissues.

Metabolism/Excretion: Unknown.

Half-Life: 6 days.

Time/Action Profile ⬆ ⬇

(effects on IGF-1)

ROUTE	ONSET	PEAK	DURATION
SUBQ	within 2 wk	4–6 wk	unknown

Patient/Family Teaching ⬆ ⬇

Instruct patient on the correct technique for administering pegvisomant. Review patient information sheet, preparation of dose, administration sites and technique, and disposal of equipment into a puncture-resistant container. Inform patient that further questions may be answered by their health care professional or by calling (800)-645-1280.
Instruct patient that missed doses should be omitted; return to schedule the next day. Do not inject a double dose to make up for a forgotten injection.
Instruct patient to inform their health care professional if they have diabetes or liver problems, or if they take opioid medications.
May cause dizziness. Caution patient to avoid driving or other activities requiring alertness until effect of the drug is known.
Advise patient to consult health care professional before taking other Rx or OTC medications, or herbal products.
Instruct patient to notify health care professional promptly if skin or whites of the eyes turn yellow (jaundice), urine turn dark, stools turn light in color, decreased appetite, nausea, unexplained tiredness, or abdominal pain occur.
Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Emphasize the need for frequent lab test to adjust dose and monitor for adverse effects.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

0009- Pharmacia and Upjohn Company LLC
- 0009-5176- SOMAVERT
  - 0009-5176-01- 1 KIT in 1 PACKAGE (0009-5176-01) * 1 mL in 1 VIAL, SINGLE-DOSE (0009-5175-01) * 1 mL in 1 VIAL, SINGLE-DOSE

0009- Pharmacia and Upjohn Company LLC
- 0009-5176- SOMAVERT
  - 0009-5176-02- 1 KIT in 1 PACKAGE (0009-5176-02) * 1 mL in 1 VIAL, SINGLE-DOSE (0009-5175-01) * 1 mL in 1 VIAL, SINGLE-DOSE

0009- Pharmacia and Upjohn Company LLC
- 0009-5178- SOMAVERT
  - 0009-5178-01- 1 KIT in 1 PACKAGE (0009-5178-01) * 1 mL in 1 VIAL, SINGLE-DOSE (0009-5177-01) * 1 mL in 1 VIAL, SINGLE-DOSE

0009- Pharmacia and Upjohn Company LLC
- 0009-5178- SOMAVERT
  - 0009-5178-02- 1 KIT in 1 PACKAGE (0009-5178-02) * 1 mL in 1 VIAL, SINGLE-DOSE (0009-5177-01) * 1 mL in 1 VIAL, SINGLE-DOSE

0009- Pharmacia and Upjohn Company LLC
- 0009-5180- SOMAVERT
  - 0009-5180-01- 1 KIT in 1 PACKAGE (0009-5180-01) * 1 mL in 1 VIAL, SINGLE-DOSE * 1 mL in 1 VIAL, SINGLE-DOSE (0009-5179-01)

0009- Pharmacia and Upjohn Company LLC
- 0009-5180- SOMAVERT
  - 0009-5180-02- 1 KIT in 1 PACKAGE (0009-5180-02) * 1 mL in 1 VIAL, SINGLE-DOSE * 1 mL in 1 VIAL, SINGLE-DOSE (0009-5179-01)

0009- Pharmacia and Upjohn Company LLC
- 0009-5199- SOMAVERT
  - 0009-5199-01- 1 KIT in 1 PACKAGE (0009-5199-01) * 1 mL in 1 VIAL, SINGLE-DOSE (0009-5201-04) * 1 mL in 1 VIAL, SINGLE-DOSE

0009- Pharmacia and Upjohn Company LLC
- 0009-5200- SOMAVERT
  - 0009-5200-01- 1 KIT in 1 PACKAGE (0009-5200-01) * 1 mL in 1 VIAL, SINGLE-DOSE (0009-5376-04) * 1 mL in 1 VIAL, SINGLE-DOSE

0009- Pharmacia and Upjohn Company LLC
- 0009-7166- SOMAVERT
  - 0009-7166-01- 1 KIT in 1 CARTON (0009-7166-01) * 1 mL in 1 VIAL, SINGLE-DOSE (0009-5175-02) * 1 mL in 1 SYRINGE (0009-5936-01)

0009- Pharmacia and Upjohn Company LLC
- 0009-7168- SOMAVERT
  - 0009-7168-01- 1 KIT in 1 CARTON (0009-7168-01) * 1 mL in 1 VIAL, SINGLE-DOSE (0009-5177-02) * 1 mL in 1 SYRINGE (0009-5936-01)

0009- Pharmacia and Upjohn Company LLC
- 0009-7188- SOMAVERT
  - 0009-7188-01- 1 KIT in 1 CARTON (0009-7188-01) * 1 mL in 1 VIAL, SINGLE-DOSE (0009-5179-02) * 1 mL in 1 SYRINGE (0009-5936-01)

0009- Pharmacia and Upjohn Company LLC
- 0009-7199- SOMAVERT
  - 0009-7199-01- 1 KIT in 1 CARTON (0009-7199-01) * 1 mL in 1 VIAL, SINGLE-DOSE (0009-5201-02) * 1 mL in 1 SYRINGE (0009-5936-01)

0009- Pharmacia and Upjohn Company LLC
- 0009-7200- SOMAVERT
  - 0009-7200-01- 1 KIT in 1 CARTON (0009-7200-01) * 1 mL in 1 VIAL, SINGLE-DOSE (0009-5376-04) * 1 mL in 1 SYRINGE (0009-5936-01)

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Indications ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇