carboprost

REMS

Induction of mid-trimester abortion.
Treatment of postpartum hemorrhage that has not responded to conventional therapy.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity;
Acute pelvic inflammatory disease;
Active pulmonary, renal, or hepatic disease.

Use Cautiously in:

Uterine scarring;
Asthma;
Hypotension;
Hypertension;
Cardiac disease;
Adrenal disease;
Anemia;
Jaundice;
Diabetes mellitus;
Seizure disorders.

Adv. Reactions/Side Effects ⬆ ⬇

Derm: flushing

GI: diarrhea, nausea, vomiting, abdominal pain, cramps

GU: UTERINE RUPTURE

Neuro: dizziness, headache

Resp: wheezing

Misc: fever, chills, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA), shivering

Interactions ⬆ ⬇

Drug-drug:

Augments the effects of other oxytocic agents.

Availability ⬆ ⬇

(Generic available)

Solution for injection: 250 mcg/mL

Route/Dosage ⬆ ⬇

Test Dose

IM (Adults ): 100 mcg.

Abortifacient

IM (Adults ): 250 mcg every 1.5–3.5 hr depending upon uterine response; may be ↑ to 500 mcg if several doses of 250 mcg produce inadequate response (not to exceed 2 days of continuous therapy or total dose of 12 mg).

Refractory Postpartum Uterine Bleeding

IM (Adults ): 250 mcg; may be repeated every 15–90 min (total dose not to exceed 2 mg).

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Causes uterine contractions by directly stimulating the myometrium.

Therapeutic effects:

Expulsion of fetus.
Control of postpartum bleeding.

Classifications ⬆ ⬇

Therapeutic Classification: abortifacients

Pharmacologic Classification: oxytocics, prostaglandins

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following IM administration.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(peak noted as mean abortion time)

ROUTE	ONSET	PEAK	DURATION
IM	unknown	16 hr	unknown

Patient/Family Teaching ⬆ ⬇

Explain purpose of vaginal examinations (to assess for trauma to cervix).
- Instruct patient to notify health care professional immediately if fever and chills, foul-smelling vaginal discharge, lower abdominal pain, or increased bleeding occurs.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

0009- Pharmacia and Upjohn Company LLC
- 0009-0856- Hemabate
  - 0009-0856-05- 1 mL in 1 AMPULE (0009-0856-05)

0009- Pharmacia and Upjohn Company LLC
- 0009-0856- Hemabate
  - 0009-0856-08- 10 AMPULE in 1 PACKAGE (0009-0856-08) > 1 mL in 1 AMPULE (0009-0856-05)

43598- Dr. Reddyøs Laboratories Inc.
- 43598-698- Carboprost Tromethamine
  - 43598-698-58- 10 VIAL, SINGLE-DOSE in 1 CARTON (43598-698-58) > 1 mL in 1 VIAL, SINGLE-DOSE (43598-698-11)

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Indications ⬇