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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: reversible alopecia

GI: ↑liver enzymes (↑ in hydatid disease), abdominal pain (hydatid disease only), nausea/vomiting (↑ in neurocysticercosis)

Hemat: AGRANULOCYTOSIS, GRANULOCYTOPENIA, PANCYTOPENIA

Neuro: headache (↑ in neurocysticercosis), ↑intracranial pressure (↑ in neurocysticercosis), dizziness/vertigo, meningeal signs (in neurocysticercosis only)

Misc: fever (hydatid disease only)

Interactions ⬆ ⬇

Drug-drug:

Drug-Food:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Hydatid Disease

Neurocysticercosis

US Brand Names ⬆ ⬇

Albenza

Action ⬆ ⬇

  • Inhibits tubulin polymerization, resulting in the loss of cytoplasmic microtubules.
Therapeutic effects:
  • Death of affected larval form of susceptible parasites.

Spectrum:

Classifications ⬆ ⬇

Therapeutic Classification: anthelmintics

Pharmacokinetics ⬆ ⬇

Absorption: Poorly absorbed following oral administration because of extensive first-pass hepatic metabolism, resulting in rapid conversion to albendazole sulfoxide, the active metabolite.

Distribution: Widely distributed.

Protein Binding: 70% bound to plasma proteins.

Metabolism/Excretion: After conversion to the sulfoxide metabolite, further hepatic metabolism to inactive compounds occurs. <1% excreted in urine; excretion is primarily via bile.

Half-Life: Albendazole sulfoxide: 8–12 hr.

Time/Action Profile ⬆ ⬇

(blood levels of albendazole sulfoxide)

ROUTEONSETPEAKDURATION
POunknown2–5 hrunknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

al-BEN-da-zole

Code ⬆

NDC Code