Advanced Colorectal Cancer
- IV (Adults): In combination with leucovorin alone or leucovorin + oxaliplatin or irinotecan: 400 mg/m2 as IV bolus on Day 1, then 2400–3000 mg/m2 continuous infusion every 2 wk; In combination with leucovorin: 500 mg/m2 as IV bolus 1 hr after leucovorin on Days 1, 8, 15, 22, 29, and 36 every 8 wk.
- IV (Adults): In combination with cyclophosphamide + epirubicin or cyclophosphamide + methotrexate: 500 mg/m2 or 600 mg/m2 on Days 1 and 28 every 28 days for 6 cycles.
Gastric Adenocarcinoma
- IV (Adults): As part of platinum-containing regimen: 200–1000 mg/m2 as IV infusion (frequency of administration and number of cycles depends on specific regimen used).
Pancreatic Adenocarcinoma
- IV (Adults): In combination with leucovorin or as part of multidrug regimen: 400 mg/m2 as IV bolus on Day 1, then 2400 mg/m2 continuous infusion every 2 wk.
Actinic (Solar) Keratoses
- Topical (Adults): Carac: Apply 0.5% cream to lesions once daily for up to 4 wk; Efudex: Apply 2% or 5% solution or cream to lesions twice daily for 2–4 wk.
Superficial Basal Cell Carcinomas
- Topical (Adults): Efudex: Apply 5% solution or cream to lesions twice daily for 3–6 wk (up to 12 wk).