Hypersensitivity to active ingredients, additives, or preservatives
OB: /Lactation: Safety not established.
Use Cautiously in:
Patients with recurrent vulvovaginal yeast infections.
Adv. Reactions/Side Effects⬆⬇
GU: irritation, vulvovaginal burning.
Interactions⬆⬇
Drug-Drug:
Not known.
Availability⬆⬇
Vaginal ointment: 6.5%OTC;
Route/Dosage⬆⬇
Vag (Adults and Children 12 yr): Vaginal ointment: 1 applicatorful (4.6 g) at bedtime as a single dose.
US Brand Names⬆⬇
1Day, Monistat-1Day, Vagistat-1
Action⬆⬇
Affects the permeability of the fungal cell wall, allowing leakage of cellular contents. Not active against bacteria.
Therapeutic Effects:
Inhibited growth and death of susceptible Candida, with decrease in accompanying symptoms of vulvovaginitis (vaginal burning, itching, discharge).
Classifications⬆⬇
Therapeutic Classification: antifungals (vaginal)
Pharmacokinetics⬆⬇
Absorption: Minimal through intact skin.
Distribution: Unknown. Action is primarily local.
Metabolism/Excretion: Negligible with local application.
Half-life: Not applicable.
Time/Action Profile⬆⬇
ROUTE
ONSET
PEAK
DURATION
Intravag
unknown
unknown
unknown
Patient/Family Teaching⬆⬇
Advise patient to avoid using tampons, douches, spermicides, or other vaginal products while using this therapy.
Instruct patient on proper use of vaginal applicator. Medication should be inserted high into the vagina at bedtime. Instruct patient to remain recumbent for at least 30 min after insertion. Advise use of sanitary napkins to prevent staining of clothing or bedding.
Advise patient to consult health care professional regarding intercourse during therapy. Vaginal medication may cause minor skin irritation in sexual partner. Advise patient to refrain from sexual contact during therapy. Advise patient that this medication may weaken latex condoms or diaphragms. Separate use by 3 days. Another method of contraception should be used during treatment.
Advise patient to report to health care professional increased skin irritation or lack of response to therapy. A second course may be necessary if symptoms persist.
Advise patient to dispose of applicator after use.