- PO (Adults ): Anaerobic infections: 7.5 mg/kg every 6 hr (not to exceed 4 g/day). Trichomoniasis: 250 mg every 8 hr for 7 days or single 2-g dose or 1 g twice daily for 1 day. Amebiasis: 500–750 mg every 8 hr for 5–10 days. H. pylori: 250 mg 4 times daily or 500 mg twice daily for 1–2 wk (with other agents). Antibiotic associated Clostridioides difficile-associated diarrhea (CDAD): 250–500 mg 3–4 times/day for 10–14 days.
- PO (Infants and Children): Anaerobic infections: 30 mg/kg/day divided every 6 hr, maximum dose: 4 g/day Trichomoniasis: 15–30 mg/kg/day divided every 8 hr for 7–10 days. Amebiasis: 35–50 mg/kg/day divided every 8 hr for 5–10 days (not to exceed 750 mg/dose). Clostridioides difficile-associated diarrhea (CDAD): 30 mg/kg/day divided every 6 hr for 7–10 days. H. pylori: 15–20 mg/kg/day divided twice daily for 4 wk.
- IV PO (Neonates 0–4 wk, <1200 g): 7.5 mg/kg every 48 hr. Postnatal age <7 days, 1200–2000 g: 7.5 mg/kg/day every 24 hr. Postnatal age <7 days, >2000 g: 15 mg/kg/day divided every 12 hr. Postnatal age >7 days, 1200–2000 g: 15 mg/kg/day divided every 12 hr. Postnatal age >7 days, >2000 g: 30 mg/kg/day divided every 12 hr.
- IV (Adults ): Anaerobic infections: Initial dose 15 mg/kg, then 7.5 mg/kg every 6–8 hr or 500 mg every 6–8 hr (not to exceed 4 g/day). Perioperative prophylaxis: Initial dose 15 mg/kg 1 hr before surgery, then 7.5 mg/kg 6 and 12 hr later. Amebiasis: 500–750 mg every 8 hr for 5–10 days.
- IV (Children ): Anaerobic infections: 30 mg/kg/day divided every 6 hr, maximum dose: 4 g/day.
- (Adults ): Acne rosacea: Apply thin film to affected area bid.
- Vag (Adults ): 0.75% vaginal gel: One applicatorful (37.5 mg) of 0.75% gel 1–2 times daily for 5 days; Nuvessa: One applicatorful (65 mg) of 1.3% gel as a single dose at bedtime; Vandazole: One applicatorful (37.5 mg) of 0.75% gel once daily for 5 days.
- Vag (Children ≥12 yr): Nuvessa: One applicatorful (65 mg) of 1.3% gel as a single dose at bedtime.
- Vag (Children Postmenarchal): Vandazole: One applicatorful (37.5 mg) of 0.75% gel once daily for 5 days.
