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Indications ⬇

BEERS REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CNS: abnormal thinking, behavior changes, hangover, dizziness, drowsiness, hallucinations, lethargy, paradoxic excitation, sleep—driving

Derm: rash

EENT: blurred vision

GI: constipation, diarrhea, nausea, vomiting

Misc: physical dependence, psychological dependence, tolerance

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Restoril

Action ⬆ ⬇

  • Acts at many levels in the CNS, producing generalized depression.
  • Effects may be mediated by GABA, an inhibitory neurotransmitter.
Therapeutic effects:
  • Relief of insomnia.

Classifications ⬆ ⬇

Therapeutic Classification: sedative/hypnotics

Pharmacologic Classification: benzodiazepines

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed after oral administration.

Distribution: Widely distributed; crosses blood-brain barrier. Probably crosses the placenta and enters breast milk. Accumulation of drug occurs with chronic dosing.

Protein Binding: 96%.

Metabolism/Excretion: Metabolized by the liver.

Half-Life: 10–20 hr.

Contr. Subst. Schedule ⬆ ⬇

Schedule IV (C-IV)

Time/Action Profile ⬆ ⬇

(sedation)

ROUTEONSETPEAKDURATION
PO30 min2–3 hr6–8 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

tem-AZ-a-pam

Code ⬆

NDC Code