magnesium salicylate

Contraindicated in:

Hypersensitivity to aspirin or other salicylates;
Cross-sensitivity with other NSAIDs may exist (less with nonaspirin salicylates);
Children or adolescents with viral infections (may increase the risk of Reye’s syndrome).

Use Cautiously in:

History of GI bleeding or ulcer disease;
Chronic alcohol use/abuse;
Severe renal disease (magnesium toxicity may occur);
Severe hepatic disease;
Geriatric patients (↑ risk of adverse reactions especially GI bleeding; more sensitive to toxic levels);
OB: Salicylates may have adverse effects on fetus and mother and in general should be avoided during pregnancy, especially during the 3rd trimester;
Lactation: Safety not established.

Adv. Reactions/Side Effects ⬆ ⬇

EENT: tinnitus

GI: dyspepsia, epigastric distress, nausea, GI BLEEDING, abdominal pain, anorexia, hepatotoxicity, vomiting

Misc: ANAPHYLAXIS AND LARYNGEAL EDEMAALLERGIC REACTIONS INCLUDING

Interactions ⬆ ⬇

Drug-drug:

May ↑ activity of penicillins, phenytoin, methotrexate, valproic acid, oral hypoglycemic agents, and sulfonamides.
May ↓ beneficial effects of probenecid.
Urinary acidification↑ reabsorption and may ↑ serum salicylate levels.
Alkalinization of the urine or the ingestion of large amounts of antacids ↑excretion and ↓ serum salicylate levels.
May blunt the therapeutic response to diuretics or other antihypertensives.
↑risk of GI irritation with NSAIDs.

Drug-Food:

Foods capable of acidifying the urine (see Food Sources for Specific Nutrients) may ↑ serum salicylate levels.

Availability ⬆ ⬇

Tablets: 304 mg^OTC; 467 mg^OTC; 545 mg; 600 mg; 650 mg

Route/Dosage ⬆ ⬇

PO (Adults ): 304 mg q 4 hr or 467 mg q 6 hr.

US Brand Names ⬆ ⬇

Doan’s Regular Strength Tablets, Magan, Mobidin

Action ⬆ ⬇

Produce analgesia and reduce inflammation and fever by inhibiting the production of prostaglandins.

Therapeutic effects:

Analgesia.
Reduction of inflammation.
Reduction of fever.

Classifications ⬆ ⬇

Therapeutic Classification: antipyretics, nonopioid analgesics

Pharmacologic Classification: salicylates

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed after oral administration.

Distribution: Rapidly and widely distributed; crosses the placenta and enter breast milk.

Metabolism/Excretion: Extensively metabolized by the liver; inactive metabolites excreted by the kidneys. Amount excreted unchanged by the kidneys depends on urine pH; as pH increases, amount excreted unchanged increases from 2–3% up to 80%.

Half-Life: 2–3 hr for low doses; up to 15–30 hr with larger doses because of saturation of liver metabolism.

Canadian Brand Names ⬆ ⬇

Doan’s Backache Pills

Time/Action Profile ⬆ ⬇

ROUTE	ONSET	PEAK	DURATION
PO	5–30 min	1–3 hr	3–6 hr

Patient/Family Teaching ⬆ ⬇

Instruct patient to take salicylates with a full glass of water and to remain in an upright position for 15–30 min after administration.
- Advise patient to report tinnitus; unusual bleeding of gums; bruising; black, tarry stools; or fever lasting longer than 3 days.
- Caution patient to avoid concurrent use of alcohol with this medication to minimize possible gastric irritation; 3 or more glasses of alcohol per day may increase the risk of GI bleeding. Caution patient to avoid taking concurrently with acetaminophen or NSAIDs for more than a few days, unless directed by health care professional to prevent analgesic nephropathy.
- Teach patients on a sodium-restricted diet to avoid effervescent tablets or buffered-aspirin preparations.
- Tablets with an acetic (vinegar-like) odor should be discarded.
- Advise patients on long-term therapy to inform health care professional of medication regimen before surgery. Salicylates may need to be withheld for 1 wk before surgery.

Pronunciation ⬆ ⬇

mag-NEE-zhum sal-I-sil-ate

Code ⬆

NDC Code

15127- Land R Distributors, Inc.
- 15127-448- Backache Aid
  - 15127-448-24- 3 BLISTER PACK in 1 CARTON (15127-448-24) > 8 TABLET, FILM COATED in 1 BLISTER PACK

55741- Dr. Reddy's Laboratories Inc.
- 55741-224- Doans Extra Strength
  - 55741-224-24- 1 BOTTLE in 1 BOX (55741-224-24) > 24 TABLET in 1 BOTTLE

59779- CVS Pharmacy
- 59779-338- Backache Relief
  - 59779-338-08- 3 BLISTER PACK in 1 CARTON (59779-338-08) > 8 TABLET, FILM COATED in 1 BLISTER PACK

63029- Medtech Products Inc.
- 63029-051- Percogesic
  - 63029-051-48- 1 BOTTLE in 1 CARTON (63029-051-48) > 48 TABLET, COATED in 1 BOTTLE

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Indications ⬇

Contraind./Precautions ⬆ ⬇