section name header

Indications

High Alert

Unlabeled Use:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Adverse reactions are noted for the combination of oxaliplatin, 5-fluorouracil and leucovorin

CV: chest pain, edema, QT interval prolongation, thromboembolism, TORSADES DE POINTES.

EENT: visual abnormalities.

F and E: dehydration, hypokalemia.

GI: diarrhea, nausea, vomiting, abdominal pain, anorexia, gastroesophageal reflux, stomatitis.

Hemat: anemia, neutropenia, thrombocytopenia, leukopenia.

Local: injection site reactions.

MS: rhabdomyolysis, back pain.

Neuro: fatigue, neurotoxicity, REVERSIBLE POSTERIOR LEUKOENCEPHALOPATHY SYNDROME.

Resp: cough, dyspnea, PULMONARY FIBROSIS.

Misc: ANAPHYLAXIS/ANAPHYLACTOID REACTIONS, fever.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

see Calculator

Renal Impairment

US Brand Names

Eloxatin

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antineoplastics

Pharmacologic Classification: alkylating agents

Pharmacokinetics

Absorption: IV administration results in complete bioavailability.

Distribution: Extensive tissue distribution.

Protein Binding: >90% (platinum).

Metabolism/Excretion: Undergoes rapid and extensive nonenzymatic biotransformation; excreted mostly by the kidneys.

Half-life: 391 hrs.

Time/Action Profile

ROUTEONSETPEAKDURATION
IVunknownunknownunknown

Patient/Family Teaching

Pronunciation

ox-A-li-pla-tin

Code

NDC Code*