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Indications

REMS


Unlabeled Use:
  • Management of chronic neuropathic pain.

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: palpitations, ARRHYTHMIAS, chest pain, edema

Derm: rash

EENT: tinnitus, blurred vision

GI: nausea, heartburn, vomiting, HEPATIC NECROSIS

Hemat: blood dyscrasias

Neuro: dizziness, nervousness, tremor, coordination difficulties, confusion, fatigue, headache, paresthesia, sleep disorder

Resp: dyspnea

Interactions

Drug-drug:

Drug-Food:

Availability

(Generic available)

Route/Dosage

US Brand Names

Mexitil

Action

  • Decreases the duration of the action potential and effective refractory period in cardiac conduction tissue by altering transport of sodium across myocardial cell membranes.
  • Has little or no effect on heart rate.
Therapeutic effects:
  • Control of ventricular arrhythmias.

Classifications

Therapeutic Classification: antiarrhythmics (class IB)

Pharmacokinetics

Absorption: Well absorbed from the GI tract.

Distribution: Enters breast milk in concentrations similar to plasma.

Metabolism/Excretion: Mostly metabolized by the liver; 10% excreted unchanged by the kidneys.

Half-Life: 10–12 hr.

Time/Action Profile

(antiarrhythmic effects)
ROUTEONSETPEAKDURATION
PO30 min–2 hr2–3 hr8–12 hr

Provided a loading dose has been given.

Patient/Family Teaching

Pronunciation

mex-IL-e-teen

Code

NDC Code