Skin/Skin Structure Infections
- PO (Adults ): 500–750 mg every 12 hr for 7–14 days.
- IV (Adults ): 400 mg every 8–12 hr for 7–14 days.
Bone and Joint Infections
- PO (Adults ): 500–750 mg every 12 hr for 4–8 wk.
- IV (Adults ): 400 mg every 8–12 hr for 4–8 wk.
Complicated Intra-Abdominal Infections
- PO (Adults ): 500 mg every 12 hr for 7–14 days.
- IV (Adults ): 400 mg every 12 hr for 7–14 days.
Infectious Diarrhea
- PO (Adults ): 500 mg every 12 hr for 5–7 days.
Typhoid Fever
- PO (Adults ): 500 mg every 12 hr for 10 days.
Uncomplicated Urethral and Cervical Gonorrhea
- PO (Adults ): 250 mg as a single dose.
Inhalational Anthrax (Postexposure)
- PO (Adults ): 500 mg every 12 hr for 60 days.
- PO (Children ): 15 mg/kg (max = 500 mg/dose) every 12 hr for 60 days.
- IV (Adults ): 400 mg every 12 hr for 60 days.
- IV (Children ): 10 mg/kg (max = 400 mg/dose) every 12 hr for 60 days.
Plague
- PO (Adults ): 500–750 mg every 12 hr for 14 days.
- PO (Children ): 15 mg/kg (max = 500 mg/dose) every 8–12 hr for 14 days.
- IV (Adults ): 400 mg every 8–12 hr for 14 days.
- IV (Children ): 10 mg/kg (max = 400 mg/dose) every 8–12 hr for 10–21 days.
Chronic Bacterial Prostatitis
- PO (Adults ): 500 mg every 12 hr for 28 days.
- IV (Adults ): 400 mg every 12 hr for 28 days.
Lower Respiratory Tract Infections
- PO (Adults ): 500–750 mg every 12 hr for 7–14 days.
- IV (Adults ): 400 mg every 8–12 hr for 7–14 days.
Nosocomial Pneumonia
- IV (Adults ): 400 mg every 8 hr for 10–14 days.
Febrile Neutropenia
- IV (Adults ): 400 mg every 8 hr for 7–14 days.
Urinary Tract Infections
- PO (Adults ): Complicated UTI or acute pyelonephritis: 250–500 mg every 12 hr for 7–14 days; Acute uncomplicated cystitis: 250 mg every 12 hr for 3 days.
- PO (Children 1–17 yr): Complicated UTI or pyelonephritis: 10–20 mg/kg (max = 750 mg/dose) every 12 hr for 10–21 days.
- IV (Adults ): 200–400 mg every 8–12 hr for 7–14 days.
- IV (Children 1–17 yr): Complicated UTI or pyelonephritis: 6–10 mg/kg (max = 400 mg/dose) every 8 hr for 10–21 days.
Acute Bacterial Sinusitis
- PO (Adults ): 500 mg every 12 hr for 10 days.
- IV (Adults ): 400 mg every 12 hr for 10 days.
Renal Impairment
- PO (Adults ): CCr 30–50 mL/min: 250–500 mg every 12 hr; CCr 5–29 mL/min: 250–500 mg every 18 hr; Hemodialysis or peritoneal dialysis: 250–500 mg every 24 hr (give dose after dialysis session).
Renal Impairment
- IV (Adults ): CCr 5–29 mL/min: 200–400 mg every 18–24 hr.
