- Hypertension (HTN) (as monotherapy or in combination with other antihypertensive agents).
- Symptomatic HF with reduced ejection fraction (
40%) after an acute MI.
40%) after an acute MI.Contraindicated in:
30 mL/min (for all patients); CCr <50 mL/min (for patients with HTN)Use Cautiously in:
Endo: gynecomastia.
F and E: HYPERKALEMIA.
GI: ↑liver enzymes, abdominal pain, diarrhea.
GU: abnormal vaginal bleeding, albuminuria.
Metab: hypercholesterolemia, hypertriglyceridemia.
Neuro: dizziness, fatigue.
Misc: flu-like symptoms.
Drug-Drug:
Hypertension
Heart Failure with Reduced Ejection Fraction Post-Myocardial Infarction
Absorption: Well absorbed following oral administration.
Distribution: Unknown.
Metabolism/Excretion: Primarily metabolized by the liver via the CYP3A isoenzyme; <5% excreted unchanged by the kidneys.
Half-life: 4–6 hr.
NDC Code*