• Topical treatment of acne vulgaris in children 12 yr.

Contraindicated in:

• Exposure to sunlight, ultraviolet lights, sunlamps and weather extremes
• Regional enteritis, ulcerative colitis or history of antibiotic-associated colitis
• Sunburn.

Use Cautiously in:

• Concurrent use of neuromuscular blocking agents
• Lactation: Use cautiously, clindamycin may enter breast milk, consider discontinuing drug or breast-feeding taking into account importance of drug to mother
• Pedi: Safe and effective use in children <12 yr not established.

Derm: photosensitivity.

GI: COLITIS, diarrhea.

Local: burning, dryness, scaling, dermatitis, erythema, exfoliation, irritation, pruritus, sunburn.

Drug-Drug:

• Avoid concurrent use of erythromycin-containing products.
• Concurrent use with neuromuscular blocking agents may result in enhanced neuromuscular blockade.

• Topical gel: clindamycin 1.2%/tretinoin 0.025% in 30 g tubes;

• Topical (Adults >12 yr): Apply once daily to affected areas.

Veltin

• Clindamycin: interferes with bacterial protein synthesis.
• Tretinoin: decreases microcomedome formation and extrusion of comedomes.
• Clindamycin is active against Propionibacterium acnes.

• Decreased severity of acne.

Therapeutic Classification: antiacne agents

Pharmacologic Classification: retinoids

Absorption: Some absorption of clindamycin follows topical administration.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-life: Unknown.

(improvement in acne)

• Instruct patient on correct procedure for application. Advise patient not to apply more than pea size amount or more frequently than once daily; may increase irritation.
• Inform patient medication may cause erythema, scaling, itching, burning or stinging. Use of products that are drying or abrasive will increase skin irritation.
• Advise patient to use sunscreen daily and protective clothing and to avoid exposure to sunlight, sunlamps, and weather extremes (wind or cold) to prevent photosensitivity reactions or skin irritation.
• Caution patient to notify health care professional if fever and diarrhea occur, especially if stool contains blood, pus, or mucus. Advise patient to stop medication and not to treat diarrhea without consulting health care professional. May occur up to several wk after discontinuation of medication.
• Notify health care professional of medication if surgery with general anesthesia is planned.
• Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
• Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

klin-da-MYE-sin/TRET-i-noin

NDC Code^*

• 0472- Actavis Pharma, Inc.
  • 0472-1790- Clindamycin Phosphate and Tretinoin
    • 0472-1790-30- 1 TUBE in 1 CARTON (0472-1790-30) > 30 g in 1 TUBE

• 0472- Actavis Pharma, Inc.
  • 0472-1790- Clindamycin Phosphate and Tretinoin
    • 0472-1790-60- 1 TUBE in 1 CARTON (0472-1790-60) > 60 g in 1 TUBE

• 16110- Almirall, LLC
  • 16110-071- VELTIN
    • 16110-071-30- 1 TUBE in 1 CARTON (16110-071-30) > 30 g in 1 TUBE

• 16110- Almirall, LLC
  • 16110-071- VELTIN
    • 16110-071-60- 1 TUBE in 1 CARTON (16110-071-60) > 60 g in 1 TUBE

• 66993- Prasco Laboratories
  • 66993-959- Clindamycin Phosphate and Tretinion
    • 66993-959-31- 1 TUBE in 1 CARTON (66993-959-31) > 30 g in 1 TUBE

• 66993- Prasco Laboratories
  • 66993-959- Clindamycin Phosphate and Tretinion
    • 66993-959-61- 1 TUBE in 1 CARTON (66993-959-61) > 60 g in 1 TUBE

• 99207- Bausch Health US, LLC
  • 99207-300- ZIANA
    • 99207-300-30- 1 TUBE in 1 CARTON (99207-300-30) > 30 g in 1 TUBE

• 99207- Bausch Health US, LLC
  • 99207-300- ZIANA
    • 99207-300-60- 1 TUBE in 1 CARTON (99207-300-60) > 60 g in 1 TUBE