Complicated Skin/Skin Structure Infections
- IV (Adults ): 500 mg every 8 hr or 1 g every 8 hr (if caused by Pseudomonas aeruginosa).
- IV (Children ≥3 mo–12 yr): 10 mg/kg (max dose = 500 mg) every 8 hr or 20 mg/kg (max dose = 1 g) every 8 hr (if caused by Pseudomonas aeruginosa).
Renal Impairment
- IV (Adults ): CCr 26–50 mL/min: 500 mg every 12 hr; CCr 10–25 mL/min: 250 mg every 12 hr; CCr <10 mL/min: 250 mg every 24 hr.
Intra-abdominal Infections
- IV (Adults ): 1 g every 8 hr.
- IV (Children ≥3 mo–12 yr): 20 mg/kg (max dose = 1 g) every 8 hr.
- IV (Children <3 mo): <32 wk gestational age (GA) and postnatal age (PNA) <2 wk: 20 mg/kg every 12 hr; <32 wk GA and PNA ≥2 wk: 20 mg/kg every 8 hr; ≥32 wk GA and PNA <2 wk: 20 mg/kg every 8 hr; ≥32 wk GA and PNA ≥2 wk: 30 mg/kg every 8 hr.
Renal Impairment
- IV (Adults ): CCr 26–50 mL/min: 1 g every 12 hr; CCr 10–25 mL/min: 500 mg every 12 hr; CCr <10 mL/min: 500 mg every 24 hr.
Bacterial Meningitis
- IV (Children ≥3 mo): 40 mg/kg (max dose = 2 g) every 8 hr.
