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Indications ⬇

BEERS REMS

Unlabeled Use:
  • Essential (familial) tremor.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: edema, orthostatic hypotension

Derm: alopecia, rash

EENT: visual changes

GI: anorexia, hepatitis, nausea, vomiting

Hemat: blood dyscrasias, folic acid deficiency, megaloblastic anemia

Neuro: ataxia, drowsiness, vertigo, excitement (↑ in children), SUICIDAL THOUGHTS

Resp: dyspnea

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Drug-Food:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Mysoline

Action ⬆ ⬇

  • Decreases neuronal excitability.
  • Increases the threshold of electric stimulation of the motor cortex.
Therapeutic effects:
  • Prevention of seizures.

Classifications ⬆ ⬇

Therapeutic Classification: anticonvulsants

Pharmacokinetics ⬆ ⬇

Absorption: 80–100% absorbed from the GI tract when administered orally.

Distribution: Widely distributed to tissues

Metabolism/Excretion: Converted to phenobarbital and another active anticonvulsant compound by the liver.

Half-Life: 3–7 hr.

Time/Action Profile ⬆ ⬇

(anticonvulsant effect)

ROUTEONSETPEAKDURATION
PO4–7 days7–10 days8–12 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

PRI-mi-done

Code ⬆

NDC Code