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Indications

BEERS REMS


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

EENT: blurred vision, dry eyes, lens opacities, pigmentary retinopathy (high doses)

CV: ARRHYTHMIAS, QT INTERVAL PROLONGATION, hypotension, tachycardia

GI: constipation, dry mouth, anorexia, drug-induced hepatitis, ileus, weight gain

GU: urinary retention, priapism

Derm: photosensitivity, pigment changes, rash

Endo: galactorrhea, amenorrhea

Hemat: AGRANULOCYTOSIS, leukopenia

Metab: hyperthermia

Neuro: NEUROLEPTIC MALIGNANT SYNDROME, sedation, extrapyramidal reactions, tardive dyskinesia

Misc: allergic reactions

Interactions

Drug-drug:

Availability

(Generic available)

Route/Dosage

US Brand Names

Mellaril

Action

  • Alters the effects of dopamine in the CNS.
  • Possesses significant anticholinergic and alpha-adrenergic blocking activity.
Therapeutic effects:
  • Diminished signs and symptoms of psychoses.

Classifications

Therapeutic Classification: antipsychotics

Pharmacologic Classification: phenothiazines

Pharmacokinetics

Absorption: Absorption from tablets is variable.

Distribution: Widely distributed, high concentrations in the CNS. Crosses the placenta and enters breast milk.

Protein Binding: 90%.

Metabolism/Excretion: Highly metabolized by the liver (primarily by CYP2D6 isoenzyme) and GI mucosa; the CYP2D6 enzyme system exhibits genetic polymorphism (7% of population may be poor metabolizers and may have significantly thioridazine concentrations and an risk of adverse effects).

Half-Life: 21–24 hr.

Time/Action Profile

(antipsychotic effects)

ROUTEONSETPEAKDURATION
POunknownunknown8–12 hr

Patient/Family Teaching

Pronunciation

thye-oh-RID-a-zeen

Code

NDC Code