Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.
REMS
- PO: Hypertension, hyperlipidemia, cardiovascular disease prevention, colorectal and gastric cancer prevention
- Topical: Dermal fungal infections including tinea corporis, cruris, and pedis.
CNS: dizziness.
GI: bad breath, diarrhea, flatulence, Irritation of the mouth, esophagus, and stomach, nausea, vomiting.
Derm: Contact dermatitis and other allergic reactions (asthma, rash, anaphylaxis [rare]), Diaphoresis.
Hemat: Chronic use or excessive dose may lead to ↓ hemoglobin production and lysis of RBCs, platelet dysfunction, prolonged bleeding time.
Misc: body odor.
Natural-Drug Products:
- Use of garlic with anticoagulants, antiplatelet agents, and thrombolytics may ↑ risk of bleeding.
- May ↓ the effectiveness of contraceptive drugs and cyclosporine.
- May ↓ plasma concentrations of saquinavir, nevirapine, delavirdine, and efavirenz.
- May ↓ isoniazid levels by 65%.
Natural-Natural Products:
- Herbs with anticoagulant or antiplatelet properties may increase bleeding risk when combined with garlic, including: angelica, anise, asafoetida, bogbean, boldo, capsicum, celery, chamomile, clove, danshen, dong quai, fenugreek, feverfew, ginger, ginkgo, Panax ginseng, horse chestnut, horseradish, licorice, meadowsweet, papain, passionflower, poplar, prickly ash, onion, quassia, red clover, , wild carrot, wild lettuce, willow, and others.
Alli sativa bulbus, Allium sativum
Therapeutic Classification: lipid-lowering agents
Absorption: Garlic oil is well absorbed.
Distribution: Unknown.
Metabolism/Excretion: Kidney and lungs.
Half-life: Unknown.