inositol

Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

REMS

Respiratory distress syndrome (RDS).
Obsessive compulsive disorder (OCD).
Panic disorder.
Polycystic ovary syndrome.
Lithium-induced psoriasis.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity.

Use Cautiously in:

Bipolar disorder;
Pregnancy and lactation.

Adv. Reactions/Side Effects ⬆ ⬇

GI: nausea

Neuro: dizziness, fatigue, headache

Interactions ⬆ ⬇

Natural-Drug Products:

Inositol levels may be ↓ by carbamazepine, lithium, and valproic acid.

Natural-Natural Products:

None.

Availability ⬆ ⬇

Injection: PowderCapsules

Route/Dosage ⬆ ⬇

PO (Adults ): Panic disorder: 12–18 grams/day. OCD: 18 grams/day. Polycystic ovary syndrome: 1200 mg/day. Lithium-induced psoriasis: 6 grams/day.
IV (Infants ): RDS: 80 mg/kg/day.

US Brand Names ⬆ ⬇

antialopecia factor, cyclohexitol, lipositol, vitamin B8

Action ⬆ ⬇

Inositol is an essential component of cell membrane phospholipids. It is a constituent of the intracellular phosphatidyl inositol second messenger system which is linked to serotonin, norepinephrine, and cholinergic receptors. It may have similar benefits as SSRIs in panic disorder and OCD. It induces ovulation by improving insulin sensitivity in women with polycystic ovary syndrome. Inositol helps psoriasis triggered by lithium through an unknown mechanism. In infants with RDS, inositol lowers inspiratory oxygen requirements, mean airway pressure, and bronchopulmonary dysplasia incidence in premature infants not receiving surfactant when compared to placebo.

Therapeutic effects:

Improvement in OCD and panic disorder symptoms.
Induces ovulation in polycystic ovary syndrome.
Improved RDS symptoms in infants with RDS.

Classifications ⬆ ⬇

Therapeutic Classification: anti-rds agents, antiobsessive agents, vitamins

Pharmacokinetics ⬆ ⬇

Absorption: Unknown.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

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Indications ⬇