Unlabeled Use:
Contraindicated in:
Use Cautiously in:
CV: hypotension, tachycardia, paradoxic bradycardia, syncope.
Derm: flushing.
GI: nausea, vomiting.
Misc: tolerance.
Drug-Drug:
Isosorbide Dinitrate
(generic available)
Isosorbide Mononitrate
(generic available)
Isosorbide Dinitrate
Isosorbide Mononitrate
Absorption: Isosorbide dinitrate undergoes extensive first-pass metabolism by the liver, resulting in 25% bioavailability; isosorbide mononitrate has 100% bioavailability (does not undergo first-pass metabolism).
Distribution: Unknown.
Metabolism/Excretion: Isosorbide dinitrate is metabolized by the liver to 2 active metabolites (5-mononitrate and 2-mononitrate). Isosorbide mononitrate is primarily metabolized by the liver to inactive metabolites; primarily excreted in urine as metabolites.
Half-life: Isosorbide dinitrate: 1 hr; isosorbide mononitrate: 5 hr.
(cardiovascular effects)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| ISDN-PO | 45–60 min | unknown | 4 hr |
| ISMN-PO | 30–60 min | unknown | 7 hr |
| ISMN-ER | unknown | unknown | 12 hr |
isosorbide dinitrate: eye-soe-SOR-bide dye-NYE-trate
isosorbide mononitrate: eye-soe-SOR-bide mo-noe-NYE-trate
NDC Code*