Contraindicated in:
Use Cautiously in:
CV: peripheral edema, ARRHYTHMIAS, chest pain, HF, hypotension, palpitations, syncope, tachycardia.
Derm: ↑sweating, dermatitis, erythema multiforme, flushing, photosensitivity, pruritus/urticaria, rash.
EENT: blurred vision, disturbed equilibrium, epistaxis, tinnitus.
Endo: gynecomastia, hyperglycemia.
GI: ↑liver enzymes, anorexia, constipation, diarrhea, dry mouth, dysgeusia, dyspepsia, nausea, vomiting.
GU: dysuria, nocturia, polyuria, sexual dysfunction, urinary frequency.
Hemat: anemia, leukopenia, thrombocytopenia.
Metab: weight gain.
MS: joint stiffness, muscle cramps.
Neuro: headache , abnormal dreams, anxiety, confusion, dizziness, drowsiness, nervousness, paresthesia, psychiatric disturbances, tremor, weakness.
Resp: cough, dyspnea.
Misc: gingival hyperplasia, STEVENS-JOHNSON SYNDROME.
Drug-Drug:
Drug-Food:
Therapeutic Classification: antianginals, antihypertensives
Pharmacologic Classification: calcium channel blockers
Absorption: Well absorbed after oral administration, but extensively metabolized, resulting in ↓ bioavailability.
Distribution: Unknown.
Protein Binding: >99%.
Metabolism/Excretion: Mostly metabolized; minimal amounts excreted unchanged by kidneys.
Half-life: 11–16 hr.
NDC Code*