• Treatment/prevention of postmenopausal osteoporosis.

Contraindicated in:

• Hypersensitivity
• Abnormalities of the esophagus that delay esophageal emptying (e.g., strictures, achalasia)
• Uncorrected hypocalcemia
• Inability to stand/sit upright for at least 60 min
• Severe renal impairment (CCr <30 mL/min)
• OB: Pregnancy.

Use Cautiously in:

• History of upper GI disorders
• Concurrent use of NSAIDs or aspirin
• Invasive dental procedures, cancer, receiving chemotherapy, corticosteroids, or angiogenesis inhibitors, poor oral hygiene, periodontal disease, dental disease, anemia, coagulopathy, infection, or poorly fitting dentures (may ↑ risk of jaw osteonecrosis)
• Lactation: Safety not established in breastfeeding
• Pedi: Safety and effectiveness not established in children
• Geri: Consider age-related ↓ in body mass, renal and hepatic function, concurrent disease states, and drug therapy in older adults.

Derm: ERYTHEMA MULTIFORME, STEVENS-JOHNSON SYNDROME.

GI: diarrhea, dyspepsia, dysphagia, ESOPHAGEAL CANCER, esophageal/gastric ulcer, esophagitis.

Local: injection site reactions.

MS: musculoskeletal pain, pain in arms/legs, femur fractures, osteonecrosis (primarily of jaw).

Resp: asthma exacerbation.

Misc: ANAPHYLAXIS.

Drug-Drug:

• Calcium-, aluminum-, magnesium-, and iron- containing products, including antacids↓ absorption (ibandronate should be taken 60 min before).
• Concurrent use of NSAIDs, including aspirin, may ↑ risk of gastric irritation.

Drug-Food:

• Milk and other foods ↓ absorption.

(Generic available)

• Tablets: 150 mg;
• Injection (prefilled syringes): 1 mg/mL;

• PO (Adults): 150 mg once monthly.
• IV (Adults): 3 mg every 3 mo.

Boniva

• Inhibits resorption of bone by inhibiting osteoclast activity.

• Reversal/prevention of progression of osteoporosis with decreased fractures.

Therapeutic Classification: bone resorption inhibitors

Pharmacologic Classification:

Absorption: 0.6% absorbed following oral administration (significantly ↓ by food).

Distribution: Rapidly binds to bone.

Protein Binding: 90.9–99.5%.

Metabolism/Excretion: 50–60% excreted in urine; unabsorbed drug is eliminated in feces.

Half-life: PO: 10–60 hr; IV: 4.6–25.5 hr.

• Advise patient to eat a balanced diet and consult health care professional about the need for supplemental calcium and vitamin D. Wait at least 60 min after administration before taking supplemental calcium and vitamin D.
  • Encourage patient to participate in regular exercise and to modify behaviors that increase the risk of osteoporosis (stop smoking, reduce alcohol consumption).
  • Inform patient that severe musculoskeletal pain may occur within days, mo, or yr after starting ibandronate. Symptoms may resolve completely after discontinuation or slow or incomplete resolution may occur. Notify health care professional if severe pain occurs.
  • Advise patient to notify health care professional if rash or signs and symptoms of osteonecrosis of the jaw (pain, numbness, swelling of or drainage from the jaw, mouth, or teeth) occur.
  • Instruct patient to notify health care professional if swallowing difficulties, chest pain, new or worsening heartburn, or trouble or pain when swallowing occurs; may be signs of problems of the esophagus.
  • Advise patient to inform health care professional of ibandronate therapy prior to dental surgery.
• Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
• PO: Instruct patient on the importance of taking as directed, first thing in the morning, 60 min before other medications, beverages, or food. Ibandronate should be taken with 6–8 oz plain water (mineral water, orange juice, coffee, and other beverages decrease absorption). Do not chew or suck on tablet. If a dose is missed, skip dose and resume the next morning; do not double doses or take later in the day. If a once-monthly dose is missed and the next scheduled dose is >7 days away, take in the morning following the date it is remembered. Resume original schedule the following mo. If the next dose is <7 days away, omit dose and take next scheduled dose. Do not discontinue without consulting health care professional.
  • Caution patient to remain upright for 60 min following dose to facilitate passage to stomach and minimize risk of esophageal irritation. Advise patient to stop taking ibandronate and contact health care professional if symptoms of esophageal irritation (new or worsening dysphagia, pain on swallowing, retrosternal pain, or heartburn) occur.
• IV: Advise patient that IV doses should not be administered sooner than every 3 mo. If a dose is missed, have health care professional administer as soon as possible; next injection should be scheduled 3 mo from last injection.

i-BAN-dro-nate

NDC Code^*

• 0004- Genentech, Inc.
  • 0004-0186- Boniva
    • 0004-0186-83- 1 BLISTER PACK in 1 BOX (0004-0186-83) > 3 TABLET, FILM COATED in 1 BLISTER PACK

• 0004- Genentech, Inc.
  • 0004-0191- Boniva
    • 0004-0191-09- 1 SYRINGE, GLASS in 1 CARTON (0004-0191-09) > 3 mL in 1 SYRINGE, GLASS

• 23155- Heritage Pharmaceuticals Inc.
  • 23155-162- Ibandronate sodium
    • 23155-162-31- 3 mL in 1 VIAL, GLASS (23155-162-31)

• 25021- Sagent Pharmaceuticals
  • 25021-827- ibandronate sodium
    • 25021-827-61- 1 SYRINGE in 1 CARTON (25021-827-61) > 3 mL in 1 SYRINGE

• 33342- Macleods Pharmaceuticals Limited
  • 33342-150- IBANDRONATE SODIUM
    • 33342-150-53- 3 CARTON in 1 BOX (33342-150-53) > 1 BLISTER PACK in 1 CARTON (33342-150-01) > 1 TABLET, FILM COATED in 1 BLISTER PACK

• 47781- Alvogen Inc.
  • 47781-103- IBANDRONATE SODIUM
    • 47781-103-21- 1 BLISTER PACK in 1 CARTON (47781-103-21) > 3 TABLET in 1 BLISTER PACK

• 47781- Alvogen Inc.
  • 47781-103- IBANDRONATE SODIUM
    • 47781-103-33- 3 BLISTER PACK in 1 BOX (47781-103-33) > 1 TABLET in 1 BLISTER PACK (47781-103-07)

• 55111- Dr. Reddy's Laboratories Limited
  • 55111-575- Ibandronate sodium
    • 55111-575-03- 3 BLISTER PACK in 1 CARTON (55111-575-03) > 1 TABLET in 1 BLISTER PACK (55111-575-11)

• 55111- Dr. Reddy's Laboratories Limited
  • 55111-575- Ibandronate sodium
    • 55111-575-43- 1 BLISTER PACK in 1 CARTON (55111-575-43) > 3 TABLET in 1 BLISTER PACK (55111-575-13)

• 55150- AuroMedics Pharma LLC
  • 55150-191- Ibandronate Sodium
    • 55150-191-83- 1 SYRINGE, GLASS in 1 CARTON (55150-191-83) > 3 mL in 1 SYRINGE, GLASS

• 60429- Golden State Medical Supply, Inc.
  • 60429-643- IBANDRONATE SODIUM
    • 60429-643-73- 3 BLISTER PACK in 1 PACKAGE (60429-643-73) > 1 TABLET, FILM COATED in 1 BLISTER PACK

• 60505- Apotex Corp
  • 60505-2795- IBANDRONATE SODIUM
    • 60505-2795-0- 3 BLISTER PACK in 1 PACKAGE (60505-2795-0) > 1 TABLET, FILM COATED in 1 BLISTER PACK

• 60505- Apotex Corp.
  • 60505-6097- Ibandronate Sodium
    • 60505-6097-0- 1 SYRINGE, GLASS in 1 CARTON (60505-6097-0) > 3 mL in 1 SYRINGE, GLASS

• 62756- Sun Pharmaceutical Industries, Inc.
  • 62756-218- IBANDRONATE SODIUM
    • 62756-218-40- 1 VIAL, SINGLE-DOSE in 1 CARTON (62756-218-40) > 3 mL in 1 VIAL, SINGLE-DOSE

• 65862- Aurobindo Pharma Limited
  • 65862-237- Ibandronate Sodium
    • 65862-237-03- 1 BLISTER PACK in 1 CARTON (65862-237-03) > 3 TABLET, FILM COATED in 1 BLISTER PACK

• 67457- Mylan Institutional LLC
  • 67457-524- ibandronate sodium
    • 67457-524-33- 1 SYRINGE, GLASS in 1 CARTON (67457-524-33) > 3 mL in 1 SYRINGE, GLASS