me-SAL-a-meen
REMS
Contraindicated in:
Use Cautiously in:
CV: pericarditis
Derm: ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMATIC SYMPTOMS (DRESS), hair loss, photosensitivity, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS
EENT: pharyngitis, rhinitis
GI: diarrhea, eructation (PO), flatulence, HEPATOTOXICITY, nausea, pancreatitis, vomiting
GU: interstitial nephritis, nephrolithiasis, renal impairment
Local: anal irritation (enema, suppository)
MS: back pain, myalgia
Neuro: headache, dizziness, malaise, weakness
Misc: acute intolerance syndrome, fever, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)
Drug-drug:
Treatment of Ulcerative Colitis
Maintenance of Remission of Ulcerative Colitis
Treatment of Ulcerative Proctosigmoiditis
Treatment of Ulcerative Proctitis
Absorption: 28% absorbed following oral administration; 10–30% absorbed from the colon, depending on retention time, following rectal administration.
Distribution: Unknown.
Half-Life: Oral: 12 hr (range 2–15 hr); Rectal: 0.5–1.5 hr.
(clinical improvement)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | unknown | unknown | 6–8 hr |
| ER | 2 hr | 9–12 hr | 24 hr |
| Rectal | 3–21 days | unknown | 24 hr |
NDC Code