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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CNS: SUICIDAL THOUGHTS, drowsiness, fatigue, agitation/irritability, depression, dizziness, psychomotor slowing, psychosis, weakness.

EENT: amblyopia, tinnitus.

Resp: cough, pharyngitis.

GI: anorexia, nausea, vomiting.

F and E: metabolic acidosis.

GU: kidney stones.

Derm: STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, oligohydrosis (↑ in children), rash.

Metab: hyperthermia (↑ in children).

Neuro: abnormal gait, hyperasthesia, incoordination, tremor.

Misc: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS).

Interactions ⬆ ⬇

Drug-Drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Zonegran

Action ⬆ ⬇

Therapeutic Effects:

Classifications ⬆ ⬇

Therapeutic Classification: anticonvulsants

Pharmacologic Classification: sulfonamides

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following oral administration.

Distribution: Binds extensively to red blood cells.

Protein Binding: 40%.

Metabolism/Excretion: Mostly metabolized by the liver; 35% excreted unchanged in urine. Some metabolism occurs via CYP3A4 enzyme system.

Half-life: 63 hr (plasma).

Time/Action Profile ⬆ ⬇

(blood levels†)

ROUTEONSETPEAKDURATION
POunknown2–6 hr24 hr

†Requires 2 wk of dosing to achieve steady-state blood levels.

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

zoe-NISS-a-mide

Code ⬆

NDC Code*