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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypotension

GI: diarrhea, hepatitis

Derm: rashes

Hemat: blood dyscrasias

Local: pain, burning at IM injection site, redness at IM injection site, stinging at IM injection site

Neuro: COMA, SEIZURES, drowsiness, depression, extrapyramidal reactions

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Renal Impairment

US Brand Names ⬆ ⬇

Tigan

Action ⬆ ⬇

  • Inhibits emetic stimulation of the chemoreceptor trigger zone in the medulla.
Therapeutic effects:
  • Decreased nausea and vomiting.

Classifications ⬆ ⬇

Therapeutic Classification: antiemetics

Pharmacologic Classification: anticholinergics

Pharmacokinetics ⬆ ⬇

Absorption: Complete absorption following oral and IM administration.

Distribution: Unknown.

Metabolism/Excretion: Metabolized by the liver; 30–50% excreted unchanged in urine.

Half-Life: 7–9 hr.

Time/Action Profile ⬆ ⬇

(antiemetic effect)

ROUTEONSETPEAKDURATION
PO10–40 minunknown3–4 hr
IM15–35 minunknown2–3 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

trye-meth-oh-BEN-za-mide

Code ⬆

NDC Code