Persistent or Chronic Immune Thrombocytopenia

• PO (Adults and Children ≥6 yr): 50 mg once daily, may be ↑ to achieve a platelet count of ≥50 × 10⁹/L (not to exceed 75 mg/day); Patients of East-/Southeast-Asian ancestry—25 mg once daily initially, may be ↑ to achieve a platelet count of ≥50 × 10⁹/L (not to exceed 75 mg/day).
• PO (Children 1–5 yr): 25 mg once daily, may be ↑ to achieve a platelet count of ≥50 × 10⁹/L (not to exceed 75 mg/day).

Hepatic Impairment

• (Adults ): Mild, moderate, or severe hepatic impairment (Child Pugh Class A, B, C): 25 mg once daily initially, may be ↑ to achieve a platelet count of ≥50 × 10⁹/L (not to exceed 75 mg/day);Patients of East-/Southeast-Asian ancestry with mild, moderate, or severe hepatic impairment (Child Pugh Class A, B, C)—12.5 mg once daily initially, may be ↑ to achieve a platelet count of ≥50 × 10⁹/L (not to exceed 75 mg/day).

Chronic Hepatitis C-Associated Thrombocytopenia

• PO (Adults ): 25 mg once daily; may be ↑ by 25 mg every 2 wk to achieve the target platelet count required to initiate antiviral therapy; during antiviral therapy, adjust dose to avoid dose ↓ of peginterferon (not to exceed 100 mg/day) .

First-Line Treatment of Severe Aplastic Anemia

• PO (Adults and Children ≥12 yr): 150 mg once daily for 6 mo; Patients of East-/Southeast-Asian ancestry—75 mg once daily for 6 mo.
• PO (Children 6–11 yr): 75 mg once daily for 6 mo; Patients of East-/Southeast-Asian ancestry—37.5 mg once daily for 6 mo.
• PO (Children 2–5 yr): 2.5 mg/kg once daily for 6 mo; Patients of East-/Southeast-Asian ancestry—1.25 mg/kg once daily for 6 mo.

Hepatic Impairment

• PO (Adults and Children ≥12 yr): Mild, moderate, or severe hepatic impairment (Child Pugh Class A, B, C): 75 mg once daily for 6 mo.

Hepatic Impairment

• PO (Adults and Children 6–11 yr): Mild, moderate, or severe hepatic impairment (Child Pugh Class A, B, C): 37.5 mg once daily for 6 mo.

Hepatic Impairment

• PO (Adults and Children 2–5 yr): Mild, moderate, or severe hepatic impairment (Child Pugh Class A, B, C): 1.25 mg/kg once daily for 6 mo.

Refractory Severe Aplastic Anemia

• PO (Adults ): 50 mg once daily; may be ↑ by 50 mg every 2 wk to achieve a platelet count of ≥50 × 10⁹/L (not to exceed 150 mg/day);Patients of East-/Southeast-Asian ancestry—25 mg once daily; may be ↑ by 50 mg every 2 wk to achieve a platelet count of ≥50 × 10⁹/L (not to exceed 150 mg/day).

Hepatic Impairment

• (Adults ): Mild, moderate, or severe hepatic impairment (Child Pugh Class A, B, C): 25 mg once daily; may be ↑ by 50 mg every 2 wk to achieve a platelet count of ≥50 × 10⁹/L (not to exceed 150 mg/day).