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Indications ⬇

REMS

Unlabeled Use:

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: supine hypertension, bradycardia

Derm: piloerection, pruritus, facial flushing, rash

GU: dysuria, urinary urge/retention/frequency

Neuro: paresthesia, anxiety, confusion, head pressure/fullness, headache, nervousness

Misc: chills, pain

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Renal Impairment

US Brand Names ⬆ ⬇

ProAmatine

Action ⬆ ⬇

  • Activation of alpha-1–adrenergic receptors in arteries and veins.
Therapeutic effects:
  • Increase in vascular tone and BP.

Classifications ⬆ ⬇

Therapeutic Classification: vasopressors

Pharmacokinetics ⬆ ⬇

Absorption: 93% absorbed following oral administration; rapidly converted to desglymidodrine, the active metabolite.

Distribution: Desglymidodrine crosses the blood-brain barrier poorly.

Metabolism/Excretion: Desglymidodrine is 80% excreted by the kidneys.

Half-Life: Midodrine: 25 min; desglymidodrine: 3–4 hr.

Time/Action Profile ⬆ ⬇

(blood levels of active metabolite)

ROUTEONSETPEAKDURATION
POrapid1–2 hr2–3 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

MYE-doe-dreen

Code ⬆

NDC Code