Contraindicated in:
Use Cautiously in:
CV: hypotension, arrhythmias, chest pain, hypertension, palpitations, QT interval prolongation, tachycardia.
Derm: rash.
EENT: blurred vision, tinnitus.
GI: dry mouth, constipation, diarrhea, excess salivation, flatulence, nausea, vomiting.
GU: erectile dysfunction, hematuria, priapism, urinary frequency.
Hemat: anemia, leukopenia.
MS: myalgia.
Neuro: drowsiness, confusion, dizziness, dysgeusia, fatigue, hallucinations, headache, insomnia, nightmares, slurred speech, SUICIDAL THOUGHTS, syncope, tremor, weakness.
Drug-Drug:
Drug-Natural Products:
Depression
Insomnia
Absorption: Well absorbed after oral administration.
Distribution: Widely distributed to tissues.
Protein Binding: 89–95%.
Metabolism/Excretion: Extensively metabolized by the liver via the CYP3A4 isoenzyme; minimal excretion of unchanged drug by the kidneys.
Half-life: 5–9 hr.
NDC Code*