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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: peripheral edema(more common when used with tadalafil)

GU: ↓sperm count

Hemat: ↓hemoglobin

Neuro: headache

Resp: PULMONARY VENO-OCCLUSIVE DISEASE

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Letairis

Action ⬆ ⬇

  • Antagonizes endogenous endothelin, resulting in vasodilation.
Therapeutic effects:
  • Improved exercise capacity and delayed clinical worsening; reduced hospitalizations (when used with tadalafil).

Classifications ⬆ ⬇

Therapeutic Classification: antihypertensives

Pharmacologic Classification: endothelin receptor antagonists

Pharmacokinetics ⬆ ⬇

Absorption: Extent of absorption following oral administration unknown.

Distribution: Unknown.

Protein Binding: 99%.

Metabolism/Excretion: Highly metabolized.

Half-Life: 15 hr (effective half-life 9 hr).

Canadian Brand Names ⬆ ⬇

Volibris

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTEONSETPEAKDURATION
POunknown2 hr24 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

am-bri-SEN-tan

Code ⬆

NDC Code