Reversal of Conscious Sedation or General Anesthesia
- IV (Adults ): 0.2 mg. Additional doses may be given at 1-min intervals until desired results are obtained, up to a total dose of 1 mg. If resedation occurs, regimen may be repeated at 20-min intervals, not to exceed 3 mg/hr.
- IV (Children ): 0.01 mg/kg (up to 0.2 mg); if the desired level of consciousness is not obtained after waiting an additional 45 sec, further injections of 0.01 mg/kg (up to 0.2 mg) can be administered and repeated at 60-sec intervals when necessary (up to a maximum of 4 additional times) to a maximum total dose of 0.05 mg/kg or 1 mg, whichever is lower. The dose should be individualized based on the patient’s response.
Suspected Benzodiazepine Overdose
- IV (Adults ): 0.2 mg. Additional 0.3 mg may be given 30 sec later. Further doses of 0.5 mg may be given at 1-min intervals, if necessary, to a total dose of 3 mg. Usual dose required is 1–3 mg. If resedation occurs, additional doses of 0.5 mg/min for 2 min may be given at 20-min intervals (given no more than 1 mg at a time, not to exceed 3 mg per hr).
- IV (Children ): Unlabeled: 0.01 mg/kg (maximum dose 0.2 mg) with repeat doses every min up to a cumulative dose of 1 mg. As an alternative to repeat doses, continuous infusions of 0.005–0.01 mg/kg/hr have been used.
