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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: EXFOLIATIVE DERMATITIS, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS

EENT: tinnitus

GI: dyspepsia, epigastric distress, nausea, GI BLEEDING, abdominal pain, anorexia, hepatotoxicity, vomiting

Misc: ANAPHYLAXIS AND LARYNGEAL EDEMAALLERGIC REACTIONS INCLUDING

Interactions ⬆ ⬇

Drug-drug:

Drug-Food:

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Amigesic, Anaflex, Disalcid, Marthritic, Mono-Gesic, Salflex, Salgesic, Salsitab

Action ⬆ ⬇

  • Produce analgesia and reduce inflammation and fever by inhibiting the production of prostaglandins.
Therapeutic effects:
  • Analgesia.
  • Reduction of inflammation.
  • Reduction of fever.

Classifications ⬆ ⬇

Therapeutic Classification: antipyretics, nonopioid analgesics

Pharmacologic Classification: salicylates

Pharmacokinetics ⬆ ⬇

Absorption: Splits into 2 molecules of salicylic acid after oral administration; absorbed in the small intestine.

Distribution: rapidly and widely distributed; cross the placenta and enter breast milk.

Metabolism/Excretion: Extensively metabolized by the liver; inactive metabolites excreted by the kidneys. Amount excreted unchanged by the kidneys depends on urine pH; as pH increases, amount excreted unchanged increases from 2–3% up to 80%.

Half-Life: 2–3 hr for low doses; up to 15–30 hr with larger doses because of saturation of liver metabolism.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
PO5–30 min1–3 hr3–6 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

SAL-sa-late

Code ⬆

NDC Code