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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: flushing.

EENT: nasal congestion, nasopharyngitis, sudden hearing/vision loss.

GU: priapism.

MS: back pain.

Neuro: headache, dizziness.

Interactions

Drug-Drug:

Availability

Route/Dosage

US Brand Names

Stendra

Action

Therapeutic Effects:

Classifications

Therapeutic Classification:erectile dysfunction agents

Pharmacologic Classification: phosphodiesterase type 5 inhibitors

Pharmacokinetics

Absorption: Rapidly absorbed following oral administration.

Distribution: Minimal amounts enter semen.

Protein Binding: 99%.

Metabolism/Excretion: Mostly metabolized by the liver (primarily by the CYP3A4 enzyme system), metabolites excreted in feces (62%) and urine (21%). One metabolite had inhibitory activity on PDE5.

Half-life: 5 hr.

Time/Action Profile

(effect on BP)

ROUTEONSETPEAKDURATION
POwithin 1 hr1–2 hrunknown

Patient/Family Teaching

Pronunciation

av-AN-a-fil

Code

NDC Code*