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Indications ⬇

IM:

IV:

BEERS REMS, High Alert

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: bradycardia, hypotension, rapid IV use onlyAPNEA, CARDIAC ARREST

Derm: rash

EENT: blurred vision

GI: constipation, diarrhea, nausea, vomiting

Neuro: dizziness, drowsiness, lethargy, ataxia, confusion, forgetfulness, hangover, headache, mental depression, rhythmic myoclonic jerking in pre-term infants, paradoxical excitation, slurred speech

Resp: respiratory depression

Misc: physical dependence, psychological dependence, tolerance

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Status Epilepticus

Preanesthetic

Anxiety

US Brand Names ⬆ ⬇

Ativan, Loreev XR

Action ⬆ ⬇

  • Depresses the CNS, probably by potentiating GABA, an inhibitory neurotransmitter.
Therapeutic effects:
  • Sedation.
  • Decreased anxiety.
  • Decreased seizures.

Classifications ⬆ ⬇

Therapeutic Classification: analgesic adjuncts, antianxiety agents, sedative/hypnotics

Pharmacologic Classification: benzodiazepines

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following oral administration. Rapidly and completely absorbed following IM administration. Sublingual absorption is more rapid than oral and is similar to IM. IV administration results in complete bioavailability.

Distribution: Widely distributed. Crosses the blood-brain barrier. Crosses the placenta; enters breast milk.

Metabolism/Excretion: Highly metabolized by the liver.

Half-Life: Full-term neonates: 18–73 hr; Older children: 6–17 hr; Adults: 10–16 hr.

Contr. Subst. Schedule ⬆ ⬇

Schedule IV (C-IV)

Time/Action Profile ⬆ ⬇

(sedation)

ROUTEONSETPEAKDURATION
PO15–60 min1–6 hr8–12 hr
PO-XRunknownunknownunknown
IM30–60 min1–2 hr‡8–12 hr
IV15–30 min15–20 min8–12 hr

‡Amnestic response.

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

lor-AZ-e-pam

Pill Image

Lorazepam_195-8791.jpg

Code ⬆

NDC Code