11 yr should be tolerating a minimum opioid dose of 20 mg of oxycodone or equivalent for 5 days before initiating ER oxycodone therapy).Contraindicated in:
Use Cautiously in:
CV: orthostatic hypotension.
Derm: flushing, sweating.
EENT: blurred vision, diplopia, miosis.
Endo: adrenal insufficiency.
GI: constipation, choking, dry mouth, GI obstruction, nausea, vomiting.
GU: urinary retention.
Neuro: confusion, sedation, dizziness, dysphoria, euphoria, floating feeling, hallucinations, headache, unusual dreams.
Resp: RESPIRATORY DEPRESSION (INCLUDING CENTRAL SLEEP APNEA AND SLEEP-RELATED HYPOXEMIA).
Misc: allodynia, opioid-induced hyperalgesia, physical dependence, psychological dependence, tolerance.
Drug-Drug:
(Generic available)
50 kg): Opioid-naive patients: 5–10 mg (immediate release [IR]) every 3–4 hr initially, as needed. Once optimal analgesia is obtained, patients with chronic pain may be converted to an equivalent 24-hr dose given in 2 divided doses as ER tablets every 12 hr.11 yr): 0.05–0.15 mg/kg (IR) every 4–6 hr as needed, as immediate-release product. Once optimal analgesia is obtained, patients with chronic pain may be converted to an equivalent 24-hr dose given in 2 divided doses as ER tablets every 12 hr.Hepatic Impairment
Therapeutic Classification: opioid analgesics
Pharmacologic Classification: opioid agonists, opioid agonists nonopioid analgesic combinations
Absorption: Well absorbed from the GI tract.
Distribution: Widely distributed to tissues.
Protein Binding: 38–45%.
Metabolism/Excretion: Mostly metabolized by the liver by the CYP3A4 isoenzyme and to a lesser extent by the CYP2D6 isoenzyme.
Half-life: 2–3 hr.
NDC Code*