glatiramer

Contraindicated in:

Hypersensitivity to glatiramer or mannitol.

Use Cautiously in:

OB: Safety not established in pregnancy;
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
Pedi: Safety and effectiveness not established in children.

Adv. Reactions/Side Effects ⬆ ⬇

CV: chest pain, palpitations, edema, syncope, tachycardia, vasodilation

Derm: flushing, pruritus, rash, sweating, erythema

EENT: rhinitis, throat constriction, nystagmus

GI: diarrhea, nausea, anorexia, HEPATOTOXICITY, vomiting

GU: urgency

Local: injection site reactions, lipoatrophy

Metab: weight gain

MS: arthralgia, back pain, hypertonia, pain

Neuro: anxiety, weakness, confusion, migraine, tremor, vertigo

Resp: dyspnea

Misc: flu-like symptoms, immediate postinjection reaction, lymphadenopathy, fever, infection

Interactions ⬆ ⬇

Drug-drug:

None reported.

Availability ⬆ ⬇

(Generic available)

Solution for injection (prefilled syringes): 20 mg/mL; 40 mg/mL

Route/Dosage ⬆ ⬇

SC (Adults ): Copaxone: 20 mg once daily or 40 mg 3 times weekly; Glatopa: 20 mg once daily.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Appears to modify the immune process thought to be responsible for MS.

Therapeutic effects:

Decreased incidence of relapses.

Classifications ⬆ ⬇

Therapeutic Classification: anti-multiple sclerosis agents

Pharmacologic Classification: immune response modifiers

Pharmacokinetics ⬆ ⬇

Absorption: Some absorption follows SUBQ administration.

Distribution: Some enters the lymphatic system.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

Canadian Brand Names ⬆ ⬇

Time/Action Profile ⬆ ⬇

ROUTE	ONSET	PEAK	DURATION
SUBQ	unknown	unknown	unknown

Patient/Family Teaching ⬆ ⬇

Instruct patient to administer medication as directed. Take missed doses as soon as remembered but omit if not remembered until next day; do not double doses. Advise patient to read Patient Information pamphlet before starting therapy and with each Rx refill in case of changes.
Advise patient not to discontinue medication or change dose or dosing schedule without consulting health care professional.
Inform patient of potential post-injection reactions (flushing, chest pain, fast heart beat, anxiety, breathing problems, tightness in throat, swelling, rash, hives, or itching). Advise patient chest pain usually begins after at least 1 month of therapy and to notify health care professional if chest pain is unusually severe or persistent.
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Home Care Issues: Instruct patient in the correct technique for self-injection, storage, and proper disposal of equipment. Provide and discuss patient package insert. Caution patient rotate injection sites and not to reuse syringe. Provide patient with a puncture-proof container for needle and syringe disposal.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

0378- Mylan Pharmaceuticals Inc.
- 0378-6960- Glatiramer Acetate
  - 0378-6960-93- 30 BLISTER PACK in 1 CARTON (0378-6960-93) > 1 SYRINGE in 1 BLISTER PACK (0378-6960-32) > 1 mL in 1 SYRINGE

0378- Mylan Pharmaceuticals Inc.
- 0378-6961- Glatiramer Acetate
  - 0378-6961-12- 12 BLISTER PACK in 1 CARTON (0378-6961-12) > 1 SYRINGE in 1 BLISTER PACK (0378-6961-32) > 1 mL in 1 SYRINGE

0781- Sandoz Inc
- 0781-3234- Glatopa
  - 0781-3234-34- 30 BLISTER PACK in 1 CARTON (0781-3234-34) > 1 SYRINGE, GLASS in 1 BLISTER PACK > 1 mL in 1 SYRINGE, GLASS (0781-3234-71)

0781- Sandoz Inc
- 0781-3250- Glatopa
  - 0781-3250-89- 12 BLISTER PACK in 1 CARTON (0781-3250-89) > 1 SYRINGE, GLASS in 1 BLISTER PACK > 1 mL in 1 SYRINGE, GLASS (0781-3250-71)

68546- Teva Neuroscience, Inc.
- 68546-317- Copaxone
  - 68546-317-30- 30 BLISTER PACK in 1 CARTON (68546-317-30) > 1 SYRINGE, GLASS in 1 BLISTER PACK > 1 mL in 1 SYRINGE, GLASS

68546- Teva Neuroscience, Inc.
- 68546-325- Copaxone
  - 68546-325-06- 6 BLISTER PACK in 1 CARTON (68546-325-06) > 1 SYRINGE, GLASS in 1 BLISTER PACK > 1 mL in 1 SYRINGE, GLASS

68546- Teva Neuroscience, Inc.
- 68546-325- Copaxone
  - 68546-325-12- 12 BLISTER PACK in 1 CARTON (68546-325-12) > 1 SYRINGE, GLASS in 1 BLISTER PACK > 1 mL in 1 SYRINGE, GLASS

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Indications ⬇

Contraind./Precautions ⬆ ⬇